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We report a case of a young male who presented with acute limb ischemia after sport. With no prior history of disease, a non-infective endocarditis of the native aortic valve was diagnosed. After surgical valve replacement, the patient suffered from acute myocardial ischemia under phenprocoumon therapy. Anti-coagulant monitoring was subsequently changed to Factor II analysis after a rare Factor VII deficiency and prothrombin mutation (G20210A) was diagnosed.
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http://dx.doi.org/10.3390/diagnostics10060384 | DOI Listing |
JACC Case Rep
July 2025
Medical Sciences Research Center, University Center for the Development of Alto Vale, Rio do Sul, Brazil; Regional Alto Vale Hospital, Rio do Sul, Brazil. Electronic address:
Background: Marantic endocarditis (ME) is a noninfectious valvular condition characterized by friable vegetations that result in platelet thrombi, often associated with advanced malignancies.
Case Summary: A 56-year-old woman admitted with asthenia, weight loss, dyspnea, and fever. Transthoracic echocardiography revealed a vegetative lesion on the ventricular side of the bicuspid aortic valve and computed tomography showed mediastinal mass.
J Med Case Rep
August 2023
Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Background: Nonbacterial thrombotic endocarditis is a rare complication of prothrombotic states such as neoplasms that can cause valvular dysfunction and life-threatening complications. Nonbacterial thrombotic endocarditis usually affects the left-sided valves; however, only a minority of cases involving the tricuspid valve have been reported in medical literature.
Case Presentation: The current report describes trivalvular involvement by nonbacterial thrombotic endocarditis in a 54-year-old Azeri female patient with metastatic colorectal carcinoma.
J Thorac Cardiovasc Surg
August 2024
Department of Thoracic and Cardiovascular Surgery, Heart, Thoracic, and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
J Rheumatol
December 2022
A. Dechartres, MD, PhD, Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpital Pitié Salpêtrière, Département de Santé Publique, Paris, France.
Objective: While myocardial impairment is a predictor of poor prognosis in antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV), little is known about valvular involvement. This study aims at describing the clinical presentation, management, and outcome of endocarditis associated with AAV.
Methods: We conducted a multicenter retrospective study in centers affiliated with the French Vasculitis Study Group.
J Gen Fam Med
November 2020
Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.
Adult-onset Still's disease can develop valve lesions. Since AOSD may complicate valvular lesion, differentiation of endocarditis in patients with AOSD is required.
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