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http://dx.doi.org/10.7861/fhj.7.1.s26 | DOI Listing |
Bioresour Technol
September 2025
State Key Laboratory of Bioreactor Engineering, Qingdao Innovation Institute of East China University of Science and Technology, East China University of Science and Technology, Shanghai 200237, China; National Center of Bio-Engineering & Technology (Shanghai), East China University of Science and T
α-Amylase is a high-value enzyme widely applied in food, feed, textile, and bioenergy industries, yet achieving stable high-level production in Aspergillus niger remains difficult due to nonlinear fermentation dynamics and limited real-time control. To this end, an AI-driven fermentation optimization framework was established by combining multivariate machine learning, Raman spectroscopy-based glucose monitoring, and time-series transcriptomics. Twelve algorithms were benchmarked, with Random Forest showing the best predictive power, while SHAP interpretation highlighted glucose as the dominant regulatory factor.
View Article and Find Full Text PDFAnn N Y Acad Sci
September 2025
BCBL, Basque Center on Cognition, Brain and Language, Donostia, Spain.
Neural tracking, the alignment of brain activity with the temporal dynamics of sensory input, is a crucial mechanism underlying perception, attention, and cognition. While this concept has gained prominence in research on speech, music, and visual processing, its definition and methodological approaches remain heterogeneous. This paper critically examines neural tracking from both theoretical and methodological perspectives, highlighting how its interpretation varies across studies.
View Article and Find Full Text PDFCrit Care Sci
September 2025
Universitätsklinikum Carl Gustav Carus - Dresden, Sachsen, Germany.
The PROtective VEntilation (PROVE) Network is a globally-recognized collaborative research group dedicated to advancing research, education, and collaboration in the field of mechanical ventilation. Established to address critical questions in intraoperative and intensive care ventilation, the network focuses on improving outcomes for patients undergoing mechanical ventilation in diverse settings, including operating rooms, intensive care units, burn units, and resource-limited environments in low- and middle-income countries. The PROVE Network is committed to generating high-quality evidence through a comprehensive portfolio of investigations, including randomized clinical trials, observational research, and meta-analyses.
View Article and Find Full Text PDFPhys Rev Lett
August 2025
University of Cambridge, DAMTP, Centre for Mathematical Sciences, Cambridge CB3 0WA, United Kingdom.
We study the elementary problem of moving an active particle by a trap with minimum work input. We show analytically that (open-loop) optimal protocols are not affected by activity, but work fluctuations are always increased. For closed-loop protocols, which rely on initial measurements of the self-propulsion, the average work has a minimum for a finite persistence time.
View Article and Find Full Text PDFNano Lett
September 2025
Pillar of Engineering Product Development, Singapore University of Technology and Design, 8 Somapah Road, Singapore 487372, Singapore.
Precise delivery of nanoliter-scale reagents is essential for high-throughput biochemical assays, yet existing platforms often lack real-time control and selective content fusion. Conventional methods rely on passive encapsulation or stochastic pairing, limiting both throughput and biochemical specificity. Here, we introduce an on-demand nanoliter delivery platform that seamlessly integrates electrical sensing, triggered droplet merging, and passive sorting in a single continuous flow.
View Article and Find Full Text PDF