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Biomedical magnesium alloy stents have become a hot bed of research focus in interventional therapy for nonvascular diseases. In this study, a numerical model for a balloon-expandable bile duct stent made of magnesium alloy with laser sculpture is developed to predict the effects of the degradation of the stent on the biomechanical behavior in the stent-bile duct coupling system. Based on a continuum damage model, the degradable model of the stent is built to understand its performance in an idealized bile duct as it is subject to corrosion over time. The degradation model developed in this study addresses the uniform corrosion and pitting corrosion. By means of the secondary development function of commercial numerical software ANSYS, the finite element analysis procedures were written to control the degradation process based on the technology of element "birth and death," and it is shown how the three-dimensional model and approach give the possibility of analyzing for the degradation mechanism of a magnesium alloy stent in the bile duct or other nonvascular cavities.
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http://dx.doi.org/10.1002/cnm.3370 | DOI Listing |
Biomaterials
September 2025
Medical Research Institute, Department of Orthopedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. Electronic address:
Contrary to the traditional strengthening route by adding multiple & high-dosage alloying elements, we here explored extremely compositional and phase-constituent "simplification" in rare earth (RE) containing biodegradable magnesium alloys for better biocompatibility. An ultra-lean Mg-0.1Pr alloy with a multiscale microstructure has been developed through casting and extrusion, which showed well-balanced performances that match the commercial Mg-based orthopedic products.
View Article and Find Full Text PDFRegen Biomater
August 2025
Shi-Changxu Innovation Center for Advanced Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.
The most significant challenge facing magnesium alloy stents is their ability to withstand complex deformation during their application. To gain a deeper understanding of the impact of stent deformation on the protective capabilities of the coating, this paper presents an amplified stent deformation model. The models were coated with either a low elongation material-Poly(D, L-lactide) (PDLLA) or a high elongation material-Poly(butylene adipate-co-terephthalate) (PBAT), followed by the application of a rapamycin-loaded PLGA as drug-eluting layer.
View Article and Find Full Text PDFLangmuir
September 2025
SERB Sponsered Microfluidics Laboratory, Department of Mechanical Engineering, Jadavpur University, Kolkata, West Bengal 700032, India.
This study investigates the dynamic behavior of water droplets impacting a superhydrophobic surface (SHS) at low Weber numbers ( < 17). SHS is fabricated by a chemical coating process on magnesium AZ31 alloy. The surfaces exhibit a Cassie-Baxter wetting state, showing a contact angle of approximately 155°on the surfaces.
View Article and Find Full Text PDFJ Phys Chem Lett
September 2025
Precise Synthesis and Function Development Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, PR China.
Herein, CuBiO microspheres were first deposited on TiO nanotube arrays to develop a p-n CuBiO/TiO heterojunction by a facile hydrothermal protocol. The variations in the photoinduced open-circuit potential, photocurrent, and electrochemical parameters of the nickel-plated magnesium alloy (Mg/Ni) demonstrated the remarkably strengthened photoelectrochemical efficiency and photocathodic protection (PCP) capability caused by the CuBiO modification. This enhancement is attributed to establishing a built-in electric field and intensified light absorption in a broadened wavelength spectrum, confirmed by the valence band XPS and ultraviolet-visible spectra.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Department of Pediatric Dentistry (Department of Preventive Dentistry), School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, No.44-1 Wenhua Road West, 250012 Jinan, Shandong, China.
Guided bone regeneration (GBR) is a prominent focus in biomedical materials research, yet few studies address practical clinical needs. GBR membranes must fulfill the "PASS" principles to be effective in surgery, but existing membranes often fall short in balancing antibacterial activity, controlled degradation, osteoinductive potential, and mechanical support. In this study, we employed laser powder bed fusion (LPBF) to fabricate a porous WE43 magnesium alloy scaffold suitable for large alveolar bone defects.
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