Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The S glycoprotein of coronaviruses is important for viral entry and pathogenesis with most variable sequences. Therefore, we analyzed the S gene sequences of SARS-CoV-2 to better understand the antigenicity and immunogenicity of this virus in this study. In phylogenetic analysis, two subtypes (SARS-CoV-2a and -b) were confirmed within SARS-CoV-2 strains. These two subtypes were divided by a novel synonymous mutation of D614G. This may play a crucial role in the evolution of SARS-CoV-2 to evade the host immune system. The region containing this mutation point was confirmed as a B-cell epitope located in the S1 domain, and SARS-CoV-2b strains exhibited severe reduced antigenic indexes compared to SARS-CoV-2a in this area. This may allow these two subtypes to have different antigenicity. If the two subtypes have different serological characteristics, a vaccine for both subtypes will be more effective to prevent COVID-19. Thus, further study is urgently required to confirm the antigenicity of these two subtypes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349911 | PMC |
| http://dx.doi.org/10.3390/vaccines8020220 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Associations of Rare Variants in the Gene with Bipolar Disorder in Chinese Population.
Neuropsychiatr Dis Treat
August 2025
Department of Mood Disorders, Qingdao Mental Health Center, Qingdao, Shandong, People's Republic of China.
Purpose: This pioneering study aimed to explore the associations between the A-kinase anchoring protein 11 () gene and bipolar disorder (BD) in a Chinese population. We sought to replicate findings from European populations regarding ultra-rare protein-truncating variants (PTVs) within exon 8 of and identify any novel rare mutations linked to Chinese BD patients.
Methods: We conducted a case-control association study, including a cohort of 284 Chinese BD patients, with the control group comprising 10,588 individuals from the China Metabolic Analytics Project (ChinaMAP) database.
Prediction of protein structural changes mediated by NS-SNPs in antibiotic resistance determinants in Streptococcus pneumoniae.
Arch Microbiol
August 2025
School of Electronics and Information, Hangzhou Dianzi University, Hangzhou, 310018, China.
Streptococcus pneumoniae (S. pneumoniae) is a gram-positive bacterium, which is a human pathogen that colonises the human nasopharyngeal region. The evolution of its resistance to many antibiotics has become a major clinical and public health problem.
View Article and Find Full Text PDFGenomic Sequence of the HLA-B*07:62:02 and HLA-C*07:02:165 Alleles.
HLA
September 2025
Federal State-Financed Scientific Institution, Kirov Research Institute of Hematology and Blood Transfusion Under the Federal Medical Biological Agency, Kirov, Russia.
The sequences of HLA-B*07:62:02 and HLA-C*07:02:165 alleles are reported.
View Article and Find Full Text PDFNon-optical, label-free electrical capacitance imaging of microorganisms.
mBio
August 2025
Department of Physics, Boston University, Boston, Massachusetts, USA.
Many fundamental insights into microbiology have come from imaging, which is typically synonymous with optical techniques. However, the sample preparation needed for many optical microscopy methods, such as labeling, fixing, or genetic modification, limits the range of species and environments we can investigate. Here, we demonstrate the use of electrical capacitance measurements as a non-optical method for imaging live microbial samples.
View Article and Find Full Text PDFDevelopment and application of a novel beta-tubulin genotyping tool reveals host-specific transmission cluster in Balantioides coli.
PLoS Negl Trop Dis
August 2025
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.
Balantioides coli is a zoonotic ciliated protozoan that infects humans and other mammals. Conventional and ITS-based genotyping approaches have limitations that hinder precise molecular epidemiological investigations. The objective of this study was to develop a new β-tubulin gene-based approach to enhance the detection and genotyping of B.
View Article and Find Full Text PDF