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A sustainable approach which works under catalyst- and solvent-free conditions for the synthesis of structurally diverse secondary amines has been uncovered. This one-pot protocol works efficiently at room temperature and is compatible with a wide range of sterically and electronically diverse aldehydes and primary amines. Notably, this simple process offers scalability, excellent functional group tolerance, chemoselectivity, and is also effective at the synthesis of biologically relevant molecules.
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http://dx.doi.org/10.1039/d0ob00740d | DOI Listing |
ACS Omega
August 2025
School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, P. R. China.
Pd-Cu bimetallic catalysts were successfully synthesized for the dehydrogenation of Bisphenol Z (BPZ) by an impregnation-reduction method. The obtained catalyst was studied by XRD, HRTEM, XPS, BET, and NH-TPD techniques and effectively applied in the highly selective cleavage dehydrogenation of BPZ to give PPP > 99% yield at 270 °C and atmospheric pressure in the solvent-free condition. It was demonstrated that the "synergistic effect" of the bimetallic catalysts could effectively promote the cleavage dehydrogenation reaction.
View Article and Find Full Text PDFChem Commun (Camb)
September 2025
Department of Chemistry Indian Institute of Technology, Kharagpur 721302, India.
A copper(II) metalorganic hydrogel has been synthesised using the ligand ((2-hydroxynaphthalen-1-yl)methyl)-L-threonine and characterised. The hydrogel is an efficient, reusable catalyst for the selective synthesis of 1,3-oxathiolane-2-thiones from the reaction of CS and epoxides under solvent-free conditions.
View Article and Find Full Text PDFPharmaceuticals (Basel)
August 2025
College of Chemistry, Jilin University, Changchun 130012, China.
Isoxazole-based molecules constitute a crucial category of heterocyclic compounds with wide-ranging applications across pharmaceutical development, advanced materials, and pesticide synthesis. Traditional synthetic approaches for isoxazole derivatives frequently encounter challenges such as extended reaction periods, severe operating conditions, and reliance on toxic solvents. As an eco-friendly alternative, sonochemistry has emerged as a promising approach for organic synthesis, offering enhanced reaction efficiency, reduced energy consumption, and improved yields.
View Article and Find Full Text PDFChem Asian J
August 2025
Department of Chemistry, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India.
A series of mononuclear bis-ligated Zn(II) octahedral complexes [Zn(L)] (Zn), [Zn(L)] (Zn), [Zn(L)] (Zn), and [Zn(L)] (Zn) have been synthesized using tridentate N/N/N donors, maleonitrile tethered, half-reduced Schiff base ligands, ((2-(benzylamino)-3-((E)-(pyridin-2-ylmethylene)amino)maleonitrile) derivatives, HL, HL, HL and HL). All the compounds were well characterized by spectroscopy and structurally. The noncovalent interactions present in the lattice of Zn-complexes were studied in detail to explain the origin of molecular architecture using Hirshfeld surface (HS) analysis.
View Article and Find Full Text PDFRSC Adv
August 2025
Department of Organic Chemistry, Faculty of Chemistry, University of Science Ho Chi Minh City 700000 Vietnam +84-908-108-824.
This study successfully demonstrates the application of GO/IL/Zn Cl as a novel and environmentally friendly catalyst for the synthesis of 2-amino-3-cyanopyridine derivatives. Using husk as a precursor, a hybrid catalyst combining graphene oxide (GO), ionic liquid (IL), and zinc chloride-based species (Zn Cl ) was produced, exhibiting higher catalytic activity, better selectivity, and outstanding recyclability. The structural and morphological features of GO/IL/Zn Cl were investigated using FT-IR spectroscopy, Raman spectroscopy, XRD analysis, ICP-MS analysis, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and thermogravimetric analysis (TGA) to elucidate their properties and establish the catalyst's efficiency and stability in organic synthesis.
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