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We propose a neural network-based feature selection (FS) scheme that can control the level of redundancy in the selected features by integrating two penalties into a single objective function. The Group Lasso penalty aims to produce sparsity in features in a grouped manner. The redundancy-control penalty, which is defined based on a measure of dependence among features, is utilized to control the level of redundancy among the selected features. Both the penalty terms involve the L -norm of weight matrix between the input and hidden layers. These penalty terms are nonsmooth at the origin, and hence, one simple but efficient smoothing technique is employed to overcome this issue. The monotonicity and convergence of the proposed algorithm are specified and proved under suitable assumptions. Then, extensive experiments are conducted on both artificial and real data sets. Empirical results explicitly demonstrate the ability of the proposed FS scheme and its effectiveness in controlling redundancy. The empirical simulations are observed to be consistent with the theoretical results.
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http://dx.doi.org/10.1109/TNNLS.2020.2980383 | DOI Listing |
Commun Chem
September 2025
Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.
Promiscuity, or selectivity on a spectrum, is an encoded feature in biomolecular anion recognition. To unravel the molecular drivers of promiscuous anion recognition, we have employed a comprehensive approach - spanning experiment and theory - with the Staphylococcus carnosus nitrate regulatory element A (ScNreA) as a model. Thermodynamic analysis reveals that ScNreA complexation with native nitrate and nitrite or non-native iodide is an exothermic process.
View Article and Find Full Text PDFLeukemia
September 2025
University Children's Hospital Zurich, Pediatric Oncology and Children's Research Center, Zurich, Switzerland.
Acute lymphoblastic leukemia (ALL) preferentially localizes in the bone marrow (BM) and displays recurrent patterns of medullary and extra-medullary involvement. Leukemic cells exploit their niche for propagation and survive selective pressure by chemotherapy in the BM microenvironment, suggesting the existence of protective mechanisms. Here, we established a three-dimensional (3D) BM mimic with human mesenchymal stromal cells and endothelial cells that resemble vasculature-like structures to explore the interdependence of leukemic cells with their microenvironment.
View Article and Find Full Text PDFLight Sci Appl
September 2025
Department of Electrical, Electronic, and Communication Engineering, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo, 112-8551, Japan.
While non-destructive in-line monitoring at manufacturing sites is essential for safe distribution cycles of pharmaceuticals, efforts are still insufficient to develop analytical systems for detailed dynamic visualisation of foreign substances and material composition in target pills. Although spectroscopies, expected towards pharma testing, have faced technical challenges in in-line setups for bulky equipment housing, this work demonstrates compact dynamic photo-monitoring systems by selectively extracting informative irradiation-wavelengths from comprehensive optical references of target pills. This work develops a non-destructive in-line dynamic inspection system for pharma agent pills with carbon nanotube (CNT) photo-thermoelectric imagers and the associated ultrabroadband sub-terahertz (THz)-infrared (IR) multi-wavelength monitoring.
View Article and Find Full Text PDFJ Phys Chem Lett
September 2025
Shandong Provincial Engineering and Technical Center of Light Manipulation, School of Physics and Electronics, Shandong Normal University, Jinan 250014, P.R. China.
Heterostructures have emerged as promising contenders for surface-enhanced Raman scattering (SERS) applications. Nevertheless, the construction of a composite SERS substrate with well-matched energy levels persists as a challenge, primarily due to the restricted selection of SERS-active materials. In this study, we successfully synthesized a Ag nanoparticles (NPs)/ZnO nanorods (NRs)/GaN heterojunction featuring type II staggered energy bands, which provides an outstanding platform for efficient SERS detection.
View Article and Find Full Text PDFJ Endod
September 2025
Dental Specialty Center, Brazilian Military Police, Minas Gerais, Brazil.
Introduction: To evaluate how stepwise enlargement in the mesial root canals of mandibular first molars affect shaping outcomes and irrigant dynamics.
Methods: The shaping ability and irrigant flow patterns in mesial canals of mandibular first molars enlarged with ProTaper Next instruments (25/.06v, 30/.