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Outcomes of patients with inflammatory rheumatic diseases have significantly improved over the last three decades, mainly due to therapeutic innovations, more timely treatment, and a recognition of the need to monitor response to treatment and to titrate treatments accordingly. Diagnostic delay remains a major challenge for all stakeholders. The combination of electronic health (eHealth) and serologic and genetic markers holds great promise to improve the current management of patients with inflammatory rheumatic diseases by speeding up access to appropriate care. The Joint Pain Assessment Scoring Tool (JPAST) project, funded by the European Union (EU) European Institute of Innovation and Technology (EIT) Health program, is a unique European project aiming to enable and accelerate personalized precision medicine for early treatment in rheumatology, ultimately also enabling prevention. The aim of the project is to facilitate these goals while at the same time, reducing cost for society and patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260666 | PMC |
http://dx.doi.org/10.2196/17507 | DOI Listing |
Trop Doct
September 2025
Additional Professor, Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Chikungunya virus (CHIKV) typically causes febrile illness and arthralgia. However, severe complications such as encephalitis, rhabdomyolysis, and multiorgan dysfunction are increasingly recognised, particularly during epidemics in endemic regions. We report a case of a 61-year old male presenting with progressive flaccid paraparesis and respiratory failure following febrile illness.
View Article and Find Full Text PDFJ Telemed Telecare
September 2025
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Izmir Katip Celebi University, Izmir, Türkiye.
IntroductionTo investigate the effectiveness of the remote video-based Strengthening and Stretching for Rheumatoid Arthritis of the Hand (SARAH) exercise program in individuals with rheumatoid arthritis (RA) with wrist involvement.MethodsSeventy-three individuals were included in the study. Wrist joint position sense, wrist joint range of motion, wrist pain, wrist morning stiffness, subjective and objective hand function, grip strength, and disease-related health status were assessed at baseline and after 12 weeks.
View Article and Find Full Text PDFStem Cells Int
August 2025
R&D Center, Wuhan Hamilton Biotechnology Co. Ltd, Wuhan, Hubei, China.
Osteoarthritis (OA) is the leading joint disease that causes joint pain and disability. Despite increasing progress regarding the therapeutic potential of human umbilical cord mesenchymal stem cells (UC-MSCs) for OA, effective strategies for the treatment of OA using UC-MSCs have not yet been developed in clinical practice. Our present study has proven that the early stage in OA rats is the main development stage of nod-like receptor heat protein domain protein 3 (NLRP3)-mediated synovial inflammation.
View Article and Find Full Text PDFPurpose: Knee osteoarthritis (OA) is the most common degenerative joint disease in the world. It results in not only physical limitation and pain, but also negatively impacts quality of life and mental wellbeing. Treatment options such as medial opening wedge high tibial osteotomy (MOWHTO) help to relieve pain and improve functionality, but there is limited literature on the effect on mental health.
View Article and Find Full Text PDFCase Rep Orthop
August 2025
Department of Orthopaedic Surgery, Nishinomiya Kaisei Hospital, Nishinomiya, Hyogo, Japan.
In recent decades, arthroscopic meniscal repair has been increasingly indicated for meniscal tears in the last decades. Although literature generally reports favorable surgical outcomes, it remains unclear whether the repaired meniscus maintains its function over the long term while performing its chondroprotective function without recurrent tear after clinical healing. A 43-year-old Japanese man who underwent meniscal repair for a bucket handle tear of the medial meniscus (MM) at the age of 15 years presented with right knee pain and catching symptoms without a preceding traumatic event.
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