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Wall rocket (Diplotaxis erucoides) is a wild edible herb traditionally consumed in the Mediterranean regions with a characteristic, pungent flavour. However, little is known about its acceptance as a potential new crop. In the present study, an hedonic test with 98 volunteers was performed in order to evaluate the potential of wall rocket as a new crop. Three products were tested corresponding to microgreens, seedlings and baby-leaves. The volatile constituents were also studied due to their probable influence on acceptance, and compared to Dijon's mustard and wasabi. The degree of acceptance was mainly related to taste and pungency. Microgreens were well accepted, whereas seedlings and baby-leaves were mainly appreciated by individuals that enjoy pungent tastes. The purchase intent was also highly related to the acceptance of taste and pungency. The volatiles profile revealed that wall rocket was rich in allyl isothiocyanate, like mustard and wasabi. This compound may be greatly responsible of the relationship between the acceptance of mustard, wasabi and wall rocket. Microgreens displayed the highest levels of isothiocyanates, although the quantity of product tested by panellists did not probably allow the appreciation of such compounds. In baby-leaves, a significant decrease in isothiocyanates GC area and relative abundances was observed. These results suggest that wall rocket microgreens would be accepted by a significant proportion of the general public since pungency is lowly perceived in the product, despite its high levels of isothiocyanates. By contrast, baby-leaves may become a crop for a cohort of consumers that enjoy pungent flavours.
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http://dx.doi.org/10.1016/j.foodres.2020.109008 | DOI Listing |
J Am Coll Cardiol
August 2025
Department of Cardiology, University of California-San Francisco, San Francisco, California, USA.
Background: Symptomatic nonobstructive hypertrophic cardiomyopathy (nHCM) lacks approved therapies. The ODYSSEY-HCM trial (A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy; NCT05582395), the largest to date in HCM patients, evaluating the efficacy of mavacamten in symptomatic adults with nHCM, did not demonstrate improvements in its primary endpoints (functional capacity and patient-reported health status).
Objectives: This exploratory analysis of the phase 3, randomized, placebo-controlled trial evaluated echocardiographic changes in nHCM patients from baseline to week 48.
J Am Coll Cardiol
August 2025
Department of Cardiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Background: No therapy is approved for patients with symptomatic nonobstructive hypertrophic cardiomyopathy (nHCM). The ODYSSEY-HCM (A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy [ODYSSEY-HCM]; NCT05582395) trial, the largest to date in patients with hypertrophic cardiomyopathy (HCM), evaluating the efficacy of mavacamten in symptomatic adults with nHCM, did not demonstrate improvements in its primary endpoints (functional capacity and patient-reported health status).
Objectives: The current exploratory analysis from the ODYSSEY-HCM trial reports the associations between: 1) baseline biomarkers (N-terminal pro-B-type natriuretic peptide [NT-proBNP] and high-sensitivity cardiac troponin I [cTnI]) with clinical, exercise, and echocardiographic characteristics; and 2) comparing changes in these biomarkers from baseline to week 48 between mavacamten and placebo groups.
Sensors (Basel)
July 2025
Zhijian Laboratory, Rocket Force University of Engineering, Xi'an 710025, China.
With the deepening of degradation, the stability and reliability of the degrading system usually becomes poor, which may lead to random jumps occurring in the degradation path. A non-homogeneous jump diffusion process model is introduced to more accurately capture this type of degradation. In this paper, the proposed degradation model is translated into a state-space model, and then the Monte Carlo simulation of the state dynamic model based on particle filtering is employed for predicting the degradation evolution and estimating the remaining useful life (RUL).
View Article and Find Full Text PDFJACC Heart Fail
August 2025
Oregon Health and Science University, Portland, Oregon, USA.
Background: Long-term safety and efficacy data for aficamten in symptomatic obstructive hypertrophic cardiomyopathy are needed.
Objectives: This study aims to evaluate 48-week experience from the ongoing FOREST-HCM (A Follow-Up, Open-Label, Research Evaluation of Sustained Treatment With Aficamten [CK-3773274] in Hypertrophic Cardiomyopathy) study.
Methods: Obstructive hypertrophic cardiomyopathy participants in an aficamten study (REDWOOD-HCM [Dose-finding Study to Evaluate the Safety, Tolerability, PK, and PD of CK-3773274 in Adults With HCM; NCT04219826]; SEQUOIA-HCM [Aficamten vs Placebo in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy; NCT05186818]) could enroll in this phase 2/3, open-label, extension study.
Plants (Basel)
May 2025
Department of Horticultural Technologies, Faculty of Horticulture, "Ion Ionescu de la Brad" Iasi University of Life Sciences, 3 M. Sadoveanu Alley, 700490 Iasi, Romania.
, a species with high nutritional value, was recently introduced in Romania, making in-depth research necessary to develop an efficient cultivation technology to increase agronomic and economic potential. Therefore, the present study aimed to evaluate the influence of three mulch treatments-white polyethylene film (WLDPE), black polyethylene film (BLDPE), and nonmulched (NM)-along with three fertilization regimes-organic (OF), chemical (ChF), and nonfertilized (NF)-on the yield and quality of the Bologna cultivar of perennial wall-rocket under the climatic conditions of northeastern Romania. The results showed that mulching with white polyethylene films significantly increased the CO assimilation rate, although it did not lead to substantial differences in agro-morphological traits compared to the non-mulched variant.
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