Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Dietary advanced glycation end products (AGEs) are involved in the pathogenesis of diabetic complications, atherosclerosis, and kidney disease. Formation of -(carboxymethyl)lysine (CML), a well-known AGEs, was evaluated from the reaction of casein from bovine milk with different reducing sugars (glucose, tagatose, and xylose) at various sugar concentrations and heating temperatures (75 and 120 °C) used in food processing to determine the best sweetener to be used in dairy products. The concentration of CML was measured using an enzyme-linked immunosorbent assay. Additionally, SDS-PAGE was carried out to observe the changes in the molecular weight of casein. The results reveal that tagatose leads to a lower CML concentration at 75 °C than glucose or xylose, whereas no significant differences are observed at 120 °C. We conclude that it would be more appropriate to use tagatose rather than glucose or xylose as a sweetener, considering the AGEs contents in heat-treated dairy products.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142190 | PMC |
| http://dx.doi.org/10.1007/s10068-019-00689-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Powdered camel milk production and changes occurring along the processing steps and storage conditions: A comprehensive review.
Food Chem
August 2025
Department of Chemical and Petroleum Engineering, Khalifa University, Abu Dhabi, United Arab Emirates. Electronic address:
Spray drying offers high-quality camel milk powder with a good nutritional and techno-functional profile. However, the thermal stress can cause whey protein denaturation, reducing the effectiveness of the bioactive components of the milk and compromising its health benefits. Camel milk caseins are more sensitive to heat, while its whey proteins exhibit greater resistance compared to those in bovine milk.
View Article and Find Full Text PDFA Biomaterial-Based Approach to Trypsin Sensing: Design and Optimization of Gelatin-Casein Films.
ACS Omega
August 2025
Institute for Matter and Systems, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Real-time postoperative monitoring systems have tremendous potential to detect postoperative complications faster before patients become systemically ill. This study investigates the potential of gelatin-casein blend films as a biodegradable, implantable biomaterial platform for trypsin detection, which is a potential biomarker for an anastomotic leak from the duodenum or proximal jejunum. Although implantability has not been verified in this case, the implantability of gelatin and casein-based biomaterials is substantiated by their demonstrated cytocompatibility as evidenced below and established utility in medical applications, as evidenced by recent advancements in biomaterials research.
View Article and Find Full Text PDFMedicinal Chemistry Perspective of 1,8-Naphthyridines as Anticancer Agents.
Chem Biodivers
August 2025
Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, India.
Cancer remains a leading cause of death worldwide, mainly due to chemo resistance and the limited chemotherapy options. 1,8-Naphthyridine (NP) is a promising scaffold in medicinal chemistry, recognized for its wide range of biological activities, including anticancer, anti-inflammatory, antimalarial, antibacterial, antiprotozoal, anti-mycobacterial, and antiplatelet effects. In addition, these synthetic derivatives have been shown to exhibit a wide range of activities, including anti-osteoporotic (α(v)β(3) antagonists), antioxidant, epidermal growth factor receptor (EGFR) inhibition, protein kinase inhibition, ionotropic effects, β-3 antagonism, anti-allergic, antimalarial, gastric anti-secretory, bronchodilator, anticonvulsant, anti-hypertensive, platelet aggregation inhibition, MDR modulation, adenosine receptor agonist, adrenoceptor antagonist, and pesticide activities.
View Article and Find Full Text PDFA review of the effects of cold plasma on reducing the allergenicity of food proteins; principles, mechanisms and applications.
Int J Biol Macromol
September 2025
Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran; Halal Research Center of IRI, Iran Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran. Electronic address:
Food allergies stem from hypersensitivity reactions caused by protein allergens that may attach to immunoglobulin E (IgE), triggering allergic responses. This review study aimed to discuss the effects of cold plasma (CP) variables on the reduction of allergenicity in food products, including crustaceans, milk, peanuts, sesame, and soybeans. Tropomyosin, casein, α and β-lactoglobulin, Ara h 1 and Ara h 2; the allergenic proteins present in sesame and soybean are among the specific allergenic proteins discussed in this study.
View Article and Find Full Text PDFSodium Caseinate Induces Apoptosis in Cytarabine-Resistant AML by Modulating SIRT1 and Chemoresistance Genes, Alone or in Combination with Cytarabine or Daunorubicin.
Int J Mol Sci
August 2025
Hematopoiesis and Leukemia Laboratory, Research Unit on Cell Differentiation and Cancer, Faculty of High Studies Zaragoza, National Autonomous University of Mexico, Mexico City 09230, Mexico.
Resistance to cytarabine (Ara-C) remains a major obstacle to the successful treatment of acute myeloid leukemia (AML). Therefore, modulating Ara-C resistance is indispensable for improving clinical outcomes. We previously demonstrated that sodium caseinate (SC), a salt derived from casein, the principal milk protein, inhibits proliferation and modulates the expression of Ara-C resistance-related genes in chemoresistant cells.
View Article and Find Full Text PDF