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http://dx.doi.org/10.21037/jtd.2019.11.20 | DOI Listing |
BMC Nurs
September 2025
Institute of Business Administration and Business Informatics, IT for the Caring Society, University of Hildesheim, Hildesheim, Germany.
Background: As populations age, informal caregivers play an increasingly vital role in long-term care, with 80% of care provided by family members in Europe. However, many individuals do not immediately recognize themselves as caregivers, especially in the early stages. This lack of awareness can increase physical and emotional stress and delay access to support services.
View Article and Find Full Text PDFJ Neural Transm (Vienna)
September 2025
Sárospatak College, Sztárai Institute, University of Tokaj, Eötvöst str. 7, Sárospatak, 3944, Hungary.
Generalized Anxiety Disorder (GAD) is characterized by excessive worry and physical symptoms of prolonged anxiety. Patients with subclinical GAD-states (sub-GAD) do not fulfill the diagnostic criteria of GAD, but they often show a disease burden similar to GAD, and the subclinical state may turn into a full syndrome. Neuroinflammation may contribute to changes in brain structures in sub-GAD, but direct evidence remains lacking.
View Article and Find Full Text PDFNature
September 2025
Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Small cell lung cancer (SCLC) is a highly aggressive type of lung cancer, characterized by rapid proliferation, early metastatic spread, frequent early relapse and a high mortality rate. Recent evidence has suggested that innervation has an important role in the development and progression of several types of cancer. Cancer-to-neuron synapses have been reported in gliomas, but whether peripheral tumours can form such structures is unknown.
View Article and Find Full Text PDFGenes Dev
September 2025
Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10027, USA;
For neurons to establish the correct connections in animal nervous systems, interactions between cell adhesion molecules (CAMs), expressed presynaptically and postsynaptically, are thought to guide neurons to their targets. Here, we assess the role that affinity between two cognate CAMs-DIP-α and Dpr10-plays in establishing the leg neuromuscular system in If affinity decreases or, surprisingly, increases past certain thresholds, motor neuron (MN) terminal branches fail to be maintained. Live imaging during development shows that when affinities are aberrant, MN filopodia are unable to productively engage their muscle targets.
View Article and Find Full Text PDFJ Neurosci
September 2025
Department of Psychology, University of California, Los Angeles.
Humans frequently make decisions that impact close others. Prior research has shown that people have stable preferences regarding such decisions and maintain rich, nuanced mental representations of their close social partners. Yet, if and how such mental representations shape social decisions preferences remains to be seen.
View Article and Find Full Text PDF