Transgenerational Epigenetics: A Window into Paternal Health Influences on Offspring.

Urol Clin North Am

Department of Physiology and Developmental Biology, Brigham Young University, 4005 Life Sciences Building, Provo, UT 84602-5255, USA. Electronic address:

Published: May 2020


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Article Abstract

Transgenerational epigenetic inheritance provides a mechanism by which environmental exposures and lifestyle decisions can affect the offspring directly through the gamete. It is this pattern of inheritance that has shed light on the fact that preconception lifestyle decisions that a father makes are significant because they can significantly impact the offspring. Understanding the epigenetic alterations in gametes and the potential implications of these changes is key to the health of future generations.

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http://dx.doi.org/10.1016/j.ucl.2019.12.010DOI Listing

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