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Transgenerational epigenetic inheritance provides a mechanism by which environmental exposures and lifestyle decisions can affect the offspring directly through the gamete. It is this pattern of inheritance that has shed light on the fact that preconception lifestyle decisions that a father makes are significant because they can significantly impact the offspring. Understanding the epigenetic alterations in gametes and the potential implications of these changes is key to the health of future generations.
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http://dx.doi.org/10.1016/j.ucl.2019.12.010 | DOI Listing |
Indian J Dermatol
September 2025
From the Dermatology Unit, Hospital Universitario Virgen de las Nieves, IBS Granada, Spain.
Hidradenitis suppurativa (HS) significantly impacts patients' quality of life, particularly in major life-changing decisions (MLCDs) such as career, relationships, and lifestyle. This cross-sectional study involving 50 HS patients identifies critical socio-demographic and clinical factors, such as female sex, disease severity, and missed treatment opportunities, influencing MLCDs. Targeted interventions to mitigate these impacts are crucial for improving patient outcomes.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Center of Reproductive Medicine, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Objective: To establish and validate a nomogram model for the quality of sleep in patients with recurrent implantation failure (RIF) and to evaluate its performance.
Methods: From January 2023 to June 2023, 484 RIF patients who underwent ART fertilization treatment at the Reproductive Medicine Center of Tongji University-affiliated Obstetrics and Gynecology Hospital were selected as the modeling set and internal validation. Additionally, from July to September 2023, 223 RIF patients who underwent ART fertilization treatment at the Reproductive Medicine Center of Tongji University-affiliated Obstetrics and Gynecology Hospital were chosen as the external validation set.
J Food Sci Technol
October 2025
KGK Science Inc., London, ON Canada.
The conventional "one-size-fits-all" approach to treating and managing type 2 diabetes mellitus (T2DM) has proven challenging. T2DM is a complex, heterogeneous disease and frequently coexists with other conditions like hypertension, obesity, and dyslipidemia, further complicating treatment decisions and outcomes. While advances in diabetes medications have been made, traditional treatment algorithms often focus on broad glycemic targets, neglecting the diverse needs of patients with different risk profiles associated with ethnicity, comorbidities, and preferences.
View Article and Find Full Text PDFJACC Case Rep
September 2025
Mayo Clinic Arizona, Phoenix, Arizona, USA. Electronic address:
Background: Managing the electronic medical record (EMR) system's inbox workload effectively is important for maintaining provider productivity and well-being.
Project Rationale: Within a cohort of cardiology nurse practitioners and physician assistants at Mayo Clinic Arizona, it was identified that managing the EMR's inbox messages was the largest contributor to high reports of burnout. Based on this finding, a quality improvement project was developed to evaluate contributing factors, and an intervention of 1 hour per day was dedicated to inbox management.