Flow Cytometry Characterization of Pluripotent Transmembrane Glycoproteins on Resident Cervix Uteri Cells in Patients Screened for Cervical Cancer.

Cancer Invest

Department of Advanced Medical and Surgical Sciences. U.O.C. Division of Clinical Immunology, Immunohematology, Transfusion Medicine and Transplant Immunology (SIMT), Regional Reference Laboratory of Transplant Immunology (LIT), University of Campania "Luigi Vanvitelli", Naples, Italy.

Published: April 2020


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Article Abstract

The aim of this study was to characterize both by flow cytometry analysis and immunohistochemistry cervix uteri cells of women screened for cervical intraepithelial neoplasia (CIN) in comparison to a group without CIN by using mesenchymal stem cell-like and hematopoietic lineage markers. A significant expression for CD29, CD38, HLA-I, and HLA-II was correlated positively to the CIN degree and it was more relevant in patients positive for human papilloma virus (HPV). Thus, identification and detailed characterization of pluripotent resident in cells could be a promising therapeutic target.

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http://dx.doi.org/10.1080/07357907.2020.1742349DOI Listing

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