98%
921
2 minutes
20
The aim of this study was to characterize both by flow cytometry analysis and immunohistochemistry cervix uteri cells of women screened for cervical intraepithelial neoplasia (CIN) in comparison to a group without CIN by using mesenchymal stem cell-like and hematopoietic lineage markers. A significant expression for CD29, CD38, HLA-I, and HLA-II was correlated positively to the CIN degree and it was more relevant in patients positive for human papilloma virus (HPV). Thus, identification and detailed characterization of pluripotent resident in cells could be a promising therapeutic target.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1080/07357907.2020.1742349 | DOI Listing |
J Environ Pathol Toxicol Oncol
January 2025
Department of Gynecology, Pucheng County People's Hospital, Weinan, China.
Long non-coding RNAs (lncRNAs) are involved in the numerous types of tumors. The aim of this study is to comprehend the pathological mechanism of lncRNA CASC19 in ovarian cancer. CASC19, miR-761 and CBX2 expression in the samples was quantitatively detected by real-time quantitative polymerase chain reaction (RT-qPCR) reaction.
View Article and Find Full Text PDFBlood Adv
September 2025
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States.
Mass spectrometry (MS) is an emerging tool in multiple myeloma that detects and quantifies monoclonal proteins in the peripheral blood with sensitivity several orders of magnitude greater than conventional serum protein electrophoresis and immunofixation. Both intact light chain (top-down) and clonotypic peptide (bottom-up) MS approaches have demonstrated sensitivity comparable to-or even surpassing-BM-based assessments using next generation flow cytometry or sequencing. However, due to the delayed clearance of paraproteins, MS may be less informative for early response assessment, underscoring the need to define the optimal timing for evaluation.
View Article and Find Full Text PDFPLoS Negl Trop Dis
September 2025
Programa de Patologia Ambiental e Experimental, Universidade Paulista (UNIP), São Paulo, Brasil.
Microsporidia causes opportunistic infections in immunosuppressed individuals. Mammals shed these spores of fungi in feces, urine, or respiratory secretions, which could contaminate water and food, thereby reaching the human body and causing infection. The oral route is the most common route of infection, although experiments have demonstrated that intraperitoneal and intravenous routes may also spread infection.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Pediatrics University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America.
ClinicalTrials.gov NCT03548818.
View Article and Find Full Text PDFJ Vis Exp
August 2025
Institute of Regenerative Medicine, and Department of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu University; Haihe Laboratory of Cell Ecosystem, Institute of Hematology, Chinese Academy of Medical Sciences; Guangdong Provincial Key Laboratory of Large Animal Models for Biomedici
Xenogeneic cell transplantation often faces significant immune rejection, even in immunodeficient animal models. Among residual immune components, macrophages can actively phagocytose transplanted human cells, posing a challenge to long-term engraftment. To address this, we developed a standardized in vitro assay to quantify macrophage-mediated phagocytosis of human versus rat red blood cells (RBCs).
View Article and Find Full Text PDF