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There has been a sharp rise of reported handheld laser-induced maculopathy (HLIM) cases over the past decade, a concerning trend that may continue due to unregulated online access to high power lasers. Though HLIM has distinct clinical features, not uncommonly it may masquerade as other retinal disorders. It is critical therefore to recognise the clinical and multimodal imaging characteristics of this important and potentially devastating condition. As HLIM patients are typically young, unique issues need to be considered, such as delayed presentation, difficult history, poor compliance and behavioural or psychiatric comorbidity. This article will review the clinical and diagnostic features of laser injury, with a special emphasis on the multimodal retinal findings. In addition, we present a unique case of HLIM, resembling the presentation of a placoid disease variant and illustrating choroidal ischaemia using advanced retinal imaging, that offers further insight into the mechanisms of laser injury and its complications. The issues addressed in this review aim to increase recognition of an increasingly important and trending condition with potentially profound visual complications.
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http://dx.doi.org/10.1038/s41433-020-0830-3 | DOI Listing |
Med Sci Monit
August 2025
Department of Ophthalmology, Military Institute of Aviation Medicine, Warsaw, Poland.
BACKGROUND At great heights, reduced oxygen levels and barometric pressure can cause retinal damage, leading to high-altitude retinopathy. Military pilots additionally experience gravitational forces from rapid changes in speed and direction, which can impair vision due to short-term retinal ischemia. This study evaluated the association between flight duration and altitude with retinal and choroidal changes on optical coherence tomography (OCT) in 44 Polish military pilots.
View Article and Find Full Text PDFWorld J Clin Pediatr
September 2025
Department of Pediatric Retina and Ocular Oncology, Postgraduate Institute of Ophthalmology, Aravind Eye Hospital, Coimbatore 641014, Tamil Nādu, India.
Background: Intra-arterial chemotherapy (IAC) has become a first-line standard treatment for retinoblastoma (RB). However, studies describing its adverse events are sparse, especially from the developing world. Our study described the outcomes and adverse events from a single center in South India.
View Article and Find Full Text PDFJ Am Heart Assoc
September 2025
State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital Wenzhou Medical University Wenzhou China.
Background: Stroke remains a leading cause of death and disability worldwide, but the therapeutic efficacies of the mainstay treatments, mechanical thrombectomy and intravenous thrombolysis, are limited due to constraints such as the narrow treatment window and the issue of reperfusion injury following restoration of blood flow. Ischemia-reperfusion (I/R) injury is characterized by the infiltration of peripheral leukocytes, which are believed to enter the central nervous system through the breakdown of the blood-brain barrier. However, the involvement of the choroid plexus (ChP), a part of the blood-cerebrospinal fluid barrier, in development of I/R injury is often overlooked.
View Article and Find Full Text PDFStem Cell Rev Rep
October 2025
The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Introduction: Neonatal hypoxia ischemia (HI) causes injury to the blood brain barrier (BBB), which in turn is associated with widespread cell loss. Cell therapies are currently being investigated for use in perinatal neuroprotection and umbilical cord blood (UCB) endothelial progenitor cells (EPCs; CD133+) have been previously shown to reduce gross neuropathology associated with HI; however, no study has investigated the effect of EPC treatment on the vulnerable BBB. Therefore, in this study, we investigated the effect of EPC treatment on BBB integrity in a neonatal rat model of HI.
View Article and Find Full Text PDFFront Med (Lausanne)
July 2025
Department of Ophthalmology, Zhejiang Hospital, Hangzhou, China.
The occlusion of the short posterior ciliary arteries (SPCAs), a severe yet infrequent ocular vascular pathology, becomes particularly uncommon when it coexists with paracentral acute middle maculopathy (PAMM). We report a rare instance involving a middle-aged male who experienced an occlusion of the posterior ciliary short artery alongside paracentral acute middle maculopathy (PAMM). A 48-year-old male patient presented with a sudden loss of vision in the upper left visual field and a slight decrease in visual acuity.
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