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We extend the step-balanced random walk [Y. Maruyama, Phys. Rev. E 96, 032135 (2017)2470-004510.1103/PhysRevE.96.032135], which was proposed for diffusion phenomena in three-dimensional discontinuous media, to systems that contain anisotropic phase zones with nonplane interfaces. What is key is threefold: For each interstep transition at discontinuous interfaces to be equilibrated by its reverse transition, incident and penetration steps are in one-to-one correspondence; at each incidence, penetration probability is determined by the normal components of an incident step and the corresponding penetration step with respect to an incident tangential plane, and for reflection, the reverse of an incident step, which satisfies the conditions for time reversibility at any interface, is used as a reflection step.
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http://dx.doi.org/10.1103/PhysRevE.101.023307 | DOI Listing |
Eur J Heart Fail
September 2025
Cardiology Department, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Aims: There is a lack of data from randomized clinical trials comparing treatment outcomes between conduction system pacing (CSP) modalities and biventricular pacing (BVP) in symptomatic patients with refractory atrial fibrillation (AF) scheduled for atrioventricular node ablation (AVNA). The CONDUCT-AF investigates whether CSP is non-inferior to BVP in improving left ventricular ejection fraction (LVEF) and clinical outcomes in heart failure (HF) patients with symptomatic AF undergoing AVNA.
Methods: This study is an investigator-initiated, prospective, randomized, multicentre clinical trial conducted across 10 European centres, enrolling 82 patients with symptomatic AF, HF with reduced LVEF, and narrow QRS.
J Gerontol A Biol Sci Med Sci
September 2025
Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Background: Ambulatory older residents in long-term care(LTC) have the highest risk of falling. However, the relationship between ambulatory activity (steps per day) and fall risk in LTC is unclear. This study examined whether baseline daily step count, functional capacity and cognitive function predicted falls in LTC residents, and whether functional capacity modified the relationship between step count and fall risk.
View Article and Find Full Text PDFIntegr Med Res
March 2026
Department of Acupuncture and Moxibustion Medicine, Pusan National University Korean Medicine Hospital, Yangsan, Republic of Korea.
Background: In the clinical practice of Korean Medicine, pharmacopuncture therapy and acupotomy (PA) are being increasingly explored as potential treatment options for degenerative lumbar spinal stenosis (LSS). In this study, we aimed to evaluate the effectiveness and safety of combining PA with conventional Korean Medicine treatment (CKMT) in patients with degenerative LSS.
Methods: A pragmatic, assessor-blinded, randomized controlled trial was conducted with 104 participants aged 40-75 years diagnosed with degenerative LSS.
Biol Methods Protoc
September 2025
School of Information and Communications Technology, Hanoi University of Science and Technology, Hanoi 100000, Vietnam.
MicroRNAs (miRNAs) play a critical role in disease mechanisms, making the identification of disease-associated miRNAs essential for precision medicine. We propose a novel computational method, multiplex-heterogeneous network for MiRNA-disease associations (MHMDA), which integrates multiple miRNA functional similarity networks and a disease similarity network into a multiplex-heterogeneous network. This approach employs a tailored random walk with restart algorithm to predict disease-miRNA associations, leveraging the complementary information from experimentally validated and predicted miRNA-target interactions, as well as disease phenotypic similarities.
View Article and Find Full Text PDFDrug Des Devel Ther
September 2025
Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People's Republic of China.
Purpose: This study aimed to compare the analgesic efficacy of liposomal bupivacaine with that of traditional ropivacaine in adductor canal blocks for patients undergoing knee arthroplasty.
Patients And Methods: A total of 119 consenting participants, who were scheduled for elective knee arthroplasty (including total knee replacement and unicompartmental knee replacement) under general anesthesia, were randomly assigned to either receive an ultrasound-guided adductor canal block with ropivacaine or liposomal bupivacaine. The primary endpoint of this study was the pain scores at 2, 24, 48, and 72 hours post-surgery.