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Article Abstract
Ethnopharmacological Relevance: The herbal pair of HuangQi-DanShen (HD) is frequently used for treating brain injury caused by cerebral ischemia (CI) in traditional Chinese medicine (TCM).
Aim Of The Study: The present work was designed to reveal the active mechanism of HD against CI.
Materials And Methods: In our work, an integrated approach combined H-NMR based metabonomics and network pharmacology was applied to decipher the protection of HD against MCAO (middle cerebral artery occlusion)-induced CI rats. Meanwhile, the indicator of neurological deficit and TTC staining were used to estimate the efficacy of HD.
Results: The results of neurological deficit test and TTC staining suggested HD could improve the brain injury in CI rats. The metabonomic result indicated that HD could significantly ameliorate 8 serum metabolites in CI rats, which were linked 71 corresponding targeted proteins obtained by Metscape. In addition, 84 targets related HD against CI were obtained by network pharmacology. At last, 5 important targets were screened as hopeful targets for the treatment of CI through integrating them.
Conclusion: The integrated method coupled H-NMR based metabonomics with network pharmacology provided the insights into the mechanisms of TCM in treating CI.
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| http://dx.doi.org/10.1016/j.jep.2020.112688 | DOI Listing |
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