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We developed a synbiotic yogurt using monk fruit extract as a sweetener and investigated the effects of feeding the yogurt to rats with type 2 diabetes induced by streptozotocin and a high-fat diet. The rats fed the synbiotic yogurt showed greater blood glucose regulation and a significant decrease in insulin resistance and glycosylated hemoglobin compared with rats fed yogurt sweetened with sucrose, and they showed a remarkable improvement in short-chain fatty acid levels and gut microbiota status. Liver and kidney damage was also ameliorated in the rats fed the synbiotic yogurt. Immunohistochemistry analysis showed that the synbiotic yogurt inhibited β-cell loss compared with the control yogurt. Consuming the synbiotic yogurt helped to restore the islets of Langerhans. Our results indicated that monk fruit extract may be a good alternative to sucrose for synbiotic yogurt products in people with type 2 diabetes to delay the progression of diabetes and associated complications.
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http://dx.doi.org/10.3168/jds.2019-17700 | DOI Listing |
NPJ Sci Food
August 2025
Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Bohouth St., Dokki, 12622, Giza, Egypt.
This study presents a novel synbiotic yogurt fortified with free and PLGA-entrapped rice straw hemicellulose hydrolyzate (RSHH) to offer immediate probiotic support and sustained prebiotic delivery. RSHH, obtained by enzymatic hydrolysis, yielded 0.5 g/g hemicellulose and was rich in xylooligosaccharides (48.
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July 2025
Departamento Microbiologia y Ecologia, Universitat de València, 46100 Burjassot (Valencia), Spain.
Allergy is recognized as a public health problem with pandemic consequences and is estimated to affect more than 50% of Europeans in 2025. Prebiotic and probiotic food implementation has recently emerged as an alternative strategy to promote immunomodulatory beneficial effects in allergic patients. Among prebiotics, algae represent a niche of research with enormous possibilities.
View Article and Find Full Text PDFJ Food Sci Technol
September 2025
Department of Bioengineering, School of Life Sciences Engineering, College of Interdisciplinary Science and Technologies, University of Tehran, Tehran, 14399-57131 Iran.
Unlabelled: In this study, microwave-assisted extraction of pectin from sour cherry pomace was accomplished and the obtained supernatant was hydrolyzed by pectinase enzyme. Afterward, the pectin-derived oligosaccharides (POS) at different concentrations (0.1, 0.
View Article and Find Full Text PDFFood Sci Nutr
July 2025
Departamento de Química Analítica y Tecnología de Alimentos, Facultad de Ciencias Ambientales y Bioquímica Universidad de Castilla-La Mancha (UCLM) Toledo España.
Functional foods consumption, included the synbiotics, has garnered attention of the consumers because of their health's benefits, being lactic acid bacteria (LAB) the microorganisms most used for their manufacturing. Twelve potential probiotic LAB strains were evaluated for cholesterol removal, phenolic content, antioxidant properties, α-glucosidase inhibitory activity (anti-diabetic effect), and in vitro angiotensin-I-converting enzyme- (ACE) inhibitory activity (anti-hypertensive effect), together with the assimilatory capacity of different prebiotics such as inulin, lactulose, β-glucans, and fructooligosaccharides, to be used in the production of a synbiotic yogur. Their anti-inflammatory potential in Caco-2 cells was also assayed.
View Article and Find Full Text PDF3 Biotech
June 2025
Department of Dairy Technology, School of Agricultural and Bioengineering, Centurion University of Technology and Management, Paralakhemundi, Odisha 761211 India.
Functional dairy foods represent a rapidly growing category in the food industry, driven by enormous consumer demand for health promotion and disease prevention. The interplay between probiotics and prebiotics in these products has the potential to enhance their overall health supports. Probiotics, such as s and species, commonly found in fermented dairy foods like yogurt, fermented milk, and whey beverages, support gut health by improving the intestinal homeostasis, that aids digestion, nutrient absorption, and strengthen the immune functionality.
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