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Article Abstract
A novel class of transmembrane anion carriers, the click-tambjamines, display remarkable anionophoric activities in model liposomes and living cells. The versatility of this building block for the generation of molecular diversity offers promise to develop future drugs based on this design.
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| http://dx.doi.org/10.1039/d0cc00643b | DOI Listing |
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Formulation and evaluation of anion transporters in nanostructured lipid carriers.
Org Biomol Chem
October 2023
Departamento de Química, Universidad de Burgos, Burgos 09001, Spain.
Six novel click-tambjamines (1-6) bearing an alkyl chain of varying length linked to the imine moiety have been formulated in nanostructured lipid carriers (NLCs) to evaluate their transmembrane anion transport activity both when free (, not encapsulated) and nanoformulated. Nanostructured lipid carriers (NLCs) are an example of drug delivery systems (DDSs) that stand out because of their versatility. In this work we show that NLCs can be used to efficiently formulate highly lipophilic anionophores and experiments conducted in model liposomes reveal that these formulations are adequate to deliver anionophores without compromising their transport activity.
View Article and Find Full Text PDFClick-tambjamines as efficient and tunable bioactive anion transporters.
Chem Commun (Camb)
March 2020
Departamento de Química, Universidad de Burgos, Burgos 09001, Spain.
A novel class of transmembrane anion carriers, the click-tambjamines, display remarkable anionophoric activities in model liposomes and living cells. The versatility of this building block for the generation of molecular diversity offers promise to develop future drugs based on this design.
View Article and Find Full Text PDF