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Background: Lumbar puncture is a common procedure that can be safely performed in most patients. Certain populations may have increased risk for complications following lumbar puncture, but the significance of basilar invagination is often underappreciated.
Case Description: A 45-year-old woman with basilar invagination received multiple lumbar punctures in the workup of acute meningitis. Preprocedural computed tomography was obtained. Following lumbar puncture, the patient developed locked-in syndrome. Magnetic resonance imaging obtained several days later demonstrated severe compression and infarction of the medulla and inferior cerebellum by the odontoid process and ectopic cerebellar tonsils. The patient was transferred but at this point, surgical decompression was not possible. She did not regain significant neurologic function.
Conclusions: Basilar invagination is a risk factor for devastating neurologic complications following lumbar puncture. Awareness of this complication and prompt recognition of its occurrence may prevent future morbidity of lumbar puncture in patients with basilar invagination.
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http://dx.doi.org/10.1016/j.wneu.2020.02.040 | DOI Listing |
Am J Perinatol
September 2025
Division of Neonatology, Nemours Children's Health at Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.
This study aimed to evaluate outcomes and resource utilization in neonates ≥35 weeks' gestation admitted to the neonatal intensive care unit (NICU) for persistent hypothermia, and to assess the incidence of early-onset sepsis (EOS) as well as the potential benefit of using the Kaiser Permanente EOS calculator for risk stratification.This retrospective study included 161 neonates born ≥35 weeks' gestation admitted to the NICU with persistent hypothermia (core temperature <36.5°C on three separate measurements) at a tertiary care hospital between April 2017 and June 2024.
View Article and Find Full Text PDFGlobal Spine J
September 2025
Department of Spinal Surgery, Zhucheng People's Hospital, Zhucheng, China.
Study DesignRetrospective cohort study.ObjectivesUnilateral percutaneous kyphoplasty (PKP) is widely used to treat osteoporotic vertebral compression fractures (OVCF) in elderly patients. Cement leakage is the most common complication and may cause serious consequences.
View Article and Find Full Text PDFChilds Nerv Syst
September 2025
Department of Neurosurgery, Division of Pediatric Neurosurgery, University of Alabama at Birmingham, Children's of Alabama, 1600 7TH Avenue South, Lowder 400, Birmingham, AL, 35233, USA.
Purpose: Diagnostic cerebral venograms are the gold standard for evaluating cerebral venous sinus stenosis (CVSS). Venous sinus stenting (VSS) and less commonly venous sinus angioplasty are emerging endovascular treatments in pediatric patients. This study examines the baseline intracranial venous pressures and postoperative endovascular outcomes in pediatric patients with CVSS.
View Article and Find Full Text PDFAlzheimers Dement
September 2025
Boston University Alzheimer's Disease Research Center and BU CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
We describe the rationale, methodology, and design of the Boston University Alzheimer's Disease Research Center (BU ADRC) Clinical Core (CC). The CC characterizes a longitudinal cohort of participants with/without brain trauma to characterize the clinical presentation, biomarker profiles, and risk factors of post-traumatic Alzheimer's disease (AD) and AD-related dementias (ADRD), including chronic traumatic encephalopathy (CTE). Participants complete assessments of traumatic brain injury (TBI) and repetitive head impacts (RHIs); annual Uniform Data Set (UDS) and supplementary evaluations; digital phenotyping; annual blood draw; magnetic resonance imaging (MRI) and lumbar puncture every 3 years; electroencephalogram (EEG); and amyloid and/or tau positron emission tomography (PET) on a subset.
View Article and Find Full Text PDFCureus
August 2025
Health and Mental Hygiene, New York City Poison Control Center, New York, USA.
Salicylate toxicity usually occurs as a result of elevated serum salicylate concentrations. Salicylate concentrations can be measured in cerebrospinal fluid (CSF), but the interpretation of these values is less well understood. Two phenomena believed to be associated with salicylate toxicity are neuroglycopenia and salicylate-induced coagulopathy, but these cases are typically not well-characterized.
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