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Three-dimensional nanostructured magnetic materials have recently been the topic of intense interest since they provide access to a host of new physical phenomena. Examples include new spin textures that exhibit topological protection, magnetochiral effects and novel ultrafast magnetic phenomena such as the spin-Cherenkov effect. Two-photon lithography is a powerful methodology that is capable of realising 3D polymer nanostructures on the scale of 100 nm. Combining this with postprocessing and deposition methodologies allows 3D magnetic nanostructures of arbitrary geometry to be produced. In this article, the physics of two-photon lithography is first detailed, before reviewing the studies to date that have exploited this fabrication route. The article then moves on to consider how non-linear optical techniques and post-processing solutions can be used to realise structures with a feature size below 100 nm, before comparing two-photon lithography with other direct write methodologies and providing a discussion on future developments.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041506 | PMC |
http://dx.doi.org/10.3390/ma13030761 | DOI Listing |
Adv Healthc Mater
September 2025
Department of Mechanical Engineering, University of Arkansas, Fayetteville, AR, 72701, USA.
3D scaffold architecture is critical for directing human neural stem cell (hNSC) fate and spatial organization. In this study, two-photon lithography (TPL) is used to fabricate microcapillary scaffolds based on the Hilbert space-filling curve as biomimetic basement membrane structures for guiding hippocampal-derived hNSC differentiation. The scaffolds feature 80 µm lumens with porous ellipsoidal membranes suspended above the substrate to provide topographical cues and permit nutrient diffusion while maintaining mechanical stability.
View Article and Find Full Text PDFSmall
September 2025
Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.
Adoptive cell transfers (ACTs) can interact specifically with inflamed tissues, but lack a mechanism for transport through viscous biological barriers such as mucus when administered locally. Further, maintaining cell function is challenging due to the loss of cellular phenotypes in diseased microenvironments. In this work, the use of magnetically controlled helical microrobots is examined to transport macrophages through physiologically representative mucus and maintain functional phenotypes through drug elution for improved cell delivery.
View Article and Find Full Text PDFConventional digital cameras combine absorbing color filter arrays with microlenses to achieve color imaging and improve efficiency. Such cameras require multi-step and multi-material fabrication processes. Several recent efforts have investigated metasurface-based color routing to combine focusing with filtering in a single functional layer with an improved efficiency.
View Article and Find Full Text PDFAdv Mater
August 2025
Department of Biomedical Engineering and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Microrobots hold immense potential in biomedical applications, including drug delivery, disease diagnostics, and minimally invasive surgeries. However, two key challenges hinder their clinical translation: achieving scalable and precision fabrication, and enabling non-invasive imaging and tracking within deep biological tissues. Magnetic particle imaging (MPI), a cutting-edge imaging modality, addresses these challenges by detecting the magnetization of nanoparticles and visualizing superparamagnetic nanoparticles (SPIONs) with sub-millimeter resolution, free from interference by biological tissues.
View Article and Find Full Text PDFAdv Mater
August 2025
Laboratory of Process Engineering, NeptunLab, Department of Microsystems Engineering (IMTEK), University of Freiburg, 79110, Freiburg, Germany.
Glasses are utilized for their outstanding optical, mechanical, and thermal properties. However, conventional production methods mostly yield in glasses with uniform compositions and material properties. Here a novel lithographic approach is presented for high-resolution 3D dopant integration at defined positions, which enables property modifications in specific regions.
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