Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Under the headline "Correlation of RANKL concentrations and VDR-FokI polymorphism on disc herniation" in the description text for Table 2, the term "allelic frequency" was used erroneously for "genotypic frequency".

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00586-020-06327-5DOI Listing

Publication Analysis

Top Keywords

vdr-foki polymorphism
8
correction interplay
4
interplay low
4
low plasma
4
plasma rankl
4
rankl vdr-foki
4
polymorphism lumbar
4
lumbar disc
4
disc herniation
4
herniation independently
4

Similar Publications

Background: Vitamin D receptor (VDR), influenced by gene polymorphisms like FokI, may affect susceptibility to infections, including coronavirus disease 2019 (COVID-19). Since studies in children are limited, we aimed to analyze the correlation between the VDR FokI variant and both the incidence and severity of COVID-19 in Egyptian children.

Methods: Seventy-seven COVID-19-positive and 107 COVID-19-negative pediatric patients were included.

View Article and Find Full Text PDF

The role of vitamin D and the VDR gene polymorphism in sepsis risk and mortality: a systematic review and meta-analysis.

Osong Public Health Res Perspect

June 2025

Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.

Background: Vitamin D regulates immune function, cell proliferation, and differentiation. Its deficiency is linked to sepsis, although the causal relationship remains unclear. Studies suggest a strong correlation between FokI polymorphism and sepsis in the context of vitamin D deficiency.

View Article and Find Full Text PDF

Background: COVID-19 manifestations range from asymptomatic to severe, and are influenced by host genetic factors. This study examined the association between vitamin D receptor (VDR) polymorphisms (TaqI and FokI) and transmembrane serine protease 2 (TMPRSS2) gene polymorphisms (rs12329760) and COVID-19 severity.

Methods And Results: 242 COVID-19 patients underwent genotyping using PCR-RFLP.

View Article and Find Full Text PDF

Painful diabetic neuropathy (PDN) is a common complication in patients with type 2 diabetes mellitus (T2DM) with disruption of vitamin D (VD) activity as one of the risk factors. Active VD exerts its biological functions through the vitamin D receptor (VDR), which polymorphisms in the VDR gene can impair. This study aims to establish VDR FokI and ApaI polymorphisms as risk factors for PDN.

View Article and Find Full Text PDF

Colloid nodules are common and benign thyroid lesions that usually progress slowly and are asymptomatic. It requires follow-up because untreated colloid nodules may develop into malignant tumor. The study aimed to examine the contributions of vitamin D receptor (VDR) expression, VDR/FokI (rs2228570) genotypes, and serum vitamin D level to the susceptibility to colloid nodules.

View Article and Find Full Text PDF