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In large-scale problems, it is common practice to select important parameters by a procedure such as the Benjamini and Hochberg procedure and construct confidence intervals (CIs) for further investigation while the false coverage-statement rate (FCR) for the CIs is controlled at a desired level. Although the well-known BY CIs control the FCR, they are uniformly inflated. In this paper, we propose two methods to construct shorter selective CIs. The first method produces shorter CIs by allowing a reduced number of selective CIs. The second method produces shorter CIs by allowing a prefixed proportion of CIs containing the values of uninteresting parameters. We theoretically prove that the proposed CIs are uniformly shorter than BY CIs and control the FCR asymptotically for independent data. Numerical results confirm our theoretical results and show that the proposed CIs still work for correlated data. We illustrate the advantage of the proposed procedures by analyzing the microarray data from a HIV study.
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http://dx.doi.org/10.1111/biom.13222 | DOI Listing |
J Neuroradiol
September 2025
Department of Diagnostic and Interventional Neuroradiology, Tours University Hospital, Tours, France; Department of Clinical Neurosciences and Diagnostic Imaging, University of Calgary, AB, Canada; Imaging Brain & Neuropsychiatry, iBrain U1253, INSERM, University of Tours, Tours, France. Electronic
Background: Selection of acute stroke patients for endovascular thrombectomy (EVT) within 6 h from symptom onset can be done using MRI or CT. However, association of either imaging modality with better clinical outcomes or shorter workflow times is still not fully understood.
Methods: We searched Medline and Ovid-Embase for studies comparing outcomes and workflow metrics between patients selected for EVT using CT or MRI from inception to November 30, 2024.
J Med Internet Res
September 2025
The Hong Kong Jockey Club Centre for Suicide Research and Prevention, University of Hong Kong, 5 Sassoon Rd, Sandy Bay, Hong Kong, 999077, China (Hong Kong), 852 2831 5232.
Background: Online text-based counseling services are becoming increasingly popular. However, their text-based nature and anonymity pose challenges in tracking and understanding shifts in help-seekers' emotional experience within a session. These characteristics make it difficult for service providers to tailor interventions to individual needs, potentially diminishing service effectiveness and user satisfaction.
View Article and Find Full Text PDFFront Immunol
September 2025
The Clinical Medical Research Center of Breast and Thyroid Tumor in Xinjiang, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi, China.
Background: The platelet to lymphocyte ratio(PLR) is widely recognized as an important biomarker of systemic inflammation and has been associated with treatment responses in breast cancer (BC) patients undergoing neoadjuvant therapy. However, existing evidence remains inconsistent. This meta-analysis aims to systematically investigate the prognostic value of PLR in BC patients receiving neoadjuvant chemotherapy (NACT).
View Article and Find Full Text PDFThe KangDuo Surgical Robot-01 (KD-SR-01) was developed as a lower-cost alternative, but its perioperative performance relative to da Vinci remains uncertain. This study aims to compare operative efficiency and perioperative safety between the KD-SR-01 and da Vinci systems in colorectal cancer (CRC) surgery. A PROSPERO-registered systematic review (CRD420251082786) searched PubMed, Embase, Web of Science, and the Cochrane Library from inception to 28 June 2025.
View Article and Find Full Text PDFBr J Ophthalmol
September 2025
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China
Purpose: There have been conflicting findings on the role of leucocyte telomere length (LTL) in the risk of age-related macular degeneration (AMD). In this study, we evaluated the associations between LTL and the risk of incident AMD and explored whether age, sex and/or genetic predisposition to AMD can modify these associations.
Methods: We conducted a longitudinal cohort study involving 332 123 AMD-free participants with complete baseline covariates and LTL data from the UK Biobank.