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http://dx.doi.org/10.3967/bes2019.119 | DOI Listing |
J Pharm Pharmacol
August 2025
Department of Pharmacognosy, Faculty of Pharmacy, Alkhartoom Square, Alexandria University, Alexandria 21521, Egypt.
Objectives: Saussurea costus (Falc.) Lipschitz is traditionally used to manage thyroid disorders; however, the components responsible for its effects on propylthiouracil (PTU)-induced hypothyroidism and their mechanisms remain unclear. This study investigated the effects of S.
View Article and Find Full Text PDFNeurobiol Dis
August 2025
Department of Otorhinolaryngology, Institute of Science Tokyo, Tokyo, Japan. Electronic address:
Hearing loss associated with SLC26A4 mutations exhibits diverse phenotypes, including congenital, acquired, progressive, and fluctuating impairments. This study investigates how pigmentation influences auditory dysfunction and immune responses in the stria vascularis using albino and pigmented Slc26a4 knockout (Slc26a4) mice. We found that albino Slc26a4 mice exhibited significantly less severe hearing loss along with reduced macrophage activation than their pigmented counterpart did.
View Article and Find Full Text PDFFASEB J
May 2025
Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Maintaining systemic Cl homeostasis plays a critical yet underappreciated role in setting the baseline and salt sensitivity of blood pressure. ClC-K2 Cl-permeable channel is localized on the basolateral membrane of the distal nephron segments. Impaired NaCl reabsorption in the thick ascending limb and distal convoluted tubule has been proposed as the underlying cause of polyuria and hypotension in patients with the Bartter's syndrome type 3 due to loss-of-function of the channel.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
May 2025
Department of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033.
Intercalated cells (ICs) in the mammalian kidney regulate circulatory pH through IC subtype-restricted actions of bicarbonate transporters: pH is elevated by Slc4a1 restricted to type A-ICs (A-ICs) and depressed by Slc26a4 in type B-IC (B-ICs). NonA-nonB-ICs (nA/nB-ICs) also produce Slc26a4 though their function is unclear. Though both nephron and ureteric progenitor lineages generate A-ICs, the former also generates nA/nB-ICs and the latter B-ICs.
View Article and Find Full Text PDFiScience
January 2025
Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-kofukai, Kita-ku, Osaka 530-8480, Japan.
Activation of thyroid-stimulating hormone receptor (TSHR) fundamentally leads to hyperthyroidism. To elucidate TSHR signaling, we conducted transcriptome analyses for hyperthyroid mice that we generated by overexpressing TSH. TSH overexpression drastically changed their thyroid transcriptome.
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