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http://dx.doi.org/10.3389/fimmu.2019.02808 | DOI Listing |
CNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
View Article and Find Full Text PDFArch Pharm Res
September 2025
College of Pharmacy and Medical Research Center, Chungbuk National University, 194-21, Osongsaengmyeong 1-ro, Osong-eup, Cheongju-si, Chungcheongbuk-do, 28160, Republic of Korea.
Atopic dermatitis (AD) is an inflammatory skin disease that produces a variety of inflammatory cytokines and chemokines. Chitinase-3-like protein 1 (CHI3L1, YKL-40) significantly contributes to AD-associated inflammatory response and is highly expressed in patients with AD. Therefore, this study elucidated the effects and potential mechanisms of human YKL-40 antibody on AD-affected skin.
View Article and Find Full Text PDFAnn Gastroenterol Surg
September 2025
Aim: The reasons behind the high prevalence of poorly differentiated gastric cancer in young females remain unclear. Therefore, this study aimed to conduct a comprehensive genetic analysis to investigate the factors responsible for the high prevalence of poorly differentiated gastric cancer in young females.
Methods: We analyzed 299 patients who underwent gastric cancer surgery at the Gunma University Hospital between April 2015 and December 2020.
Pediatr Obes
September 2025
Clinical Developmental Psychology, Ghent University, Ghent, Belgium.
Intra-familial weight stigma is a subtle yet impactful dynamic that may influence the outcomes of family-based interventions aimed at treating childhood obesity. While much attention has been paid to societal and peer-related weight stigma, less focus has been placed on how stigma manifests within families. This position statement highlights the importance of recognising that such stigma can unintentionally arise in the home.
View Article and Find Full Text PDFClin Spine Surg
September 2025
Department of Orthopaedic Surgery, Duke University, Durham, NC.
Study Design: Narrative review.
Objective: To synthesize current knowledge on radiographic parameters, classification systems, and compensatory mechanisms essential to the diagnosis and surgical planning of cervical spine deformity (CD) correction.
Summary Of Background Data: CD encompasses a heterogeneous set of conditions associated with neurological impairment and impaired health-related quality of life.