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Volunteering With Mild Cognitive Impairment: Implications for Subsequent Cognitive Changes.
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Department of Child Development and Family Studies, College of Human Ecology, Seoul National University, Seoul, South Korea.
Background And Objectives: Volunteering has cognitive benefits in later life and has been theorized to protect against Alzheimer's disease and related dementias (ADRD). A small but growing body of volunteer programs target people with mild cognitive impairment (MCI)-who are presumably at elevated risk for ADRD, but we know surprisingly little about who volunteers with MCI and how volunteering affects their subsequent cognitive changes. The current study sought to address these gaps.
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Department of Mathematics and Faculty of Medicine, The University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
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Unlabelled: Cholesterol 25-hydroxylase (CH25H), an interferon-stimulated gene (ISG), has been implicated in broad-spectrum antiviral immunity. Here, we identify CH25H as a potent suppressor of hepatitis B virus (HBV) replication that significantly outperforms IFN-α in reducing HBV DNA, pregenomic RNA (pgRNA), HBsAg, and HBeAg, without inducing cytotoxicity. However, CH25H is weakly expressed in hepatocytes and only modestly induced by type I interferon.
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Immune-mediated necrotizing myopathy (IMNM) is an emerging and severe form of myositis. Most patients experience persistent muscle weakness or recurrent attacks within their lifetime. The previous view suggests that autoimmune and complement activation play a key role in muscle damage, and aggressive immunotherapy may benefit patients.
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