Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The proportion of people suffering from cardiovascular diseases has risen by 34% in the last 15 years in India. Cardiomyopathy is among the many forms of CVD s present. Infection of heart muscles is the suspected etiological agent for the same. Oral pathogens gaining entry into the bloodstream are responsible for such infections. is an oral pathogen with implications in cardiovascular diseases. Previous studies have shown certain strains of are found predominantly within atherosclerotic plaques and extirpated valves. To decipher the genetic differences responsible for endothelial cell invasion, we have sequenced the genome of B14. Pan-genome analysis, search for adhesion proteins through a special algorithm, and protein-protein interactions search through HPIDB have been done. Pan-genome analysis of 187 whole genomes, assemblies revealed 6965 genes in total and 918 genes forming the core gene cluster. Adhesion to the endothelial cell is a critical virulence factor distinguishing virulent and non-virulent strains. Overall, 4% of the total proteins in B14 were categorized as adhesion proteins. Protein-protein interaction between putative adhesion proteins and Human extracellular matrix components was predicted, revealing novel interactions. A conserved gene catalyzing the synthesis of branched-chain amino acids in B14 shows possible interaction with isoforms of cathepsin protein of the ECM. This genome sequence analysis indicates towards other proteins in the genome, which might have a specific role to play in host cell interaction.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842392 | PMC |
| http://dx.doi.org/10.1007/s12088-019-00823-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Leveraging GPT-4o for Automated Extraction and Categorization of CAD-RADS Features From Free-Text Coronary CT Angiography Reports: Diagnostic Study.
JMIR Med Inform
September 2025
Departments of Radiology, The Third Affiliated Hospital, Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, Guangdong, 510630, China, 86 18922109279, 86 20852523108.
Background: Despite the Coronary Artery Reporting and Data System (CAD-RADS) providing a standardized approach, radiologists continue to favor free-text reports. This preference creates significant challenges for data extraction and analysis in longitudinal studies, potentially limiting large-scale research and quality assessment initiatives.
Objective: To evaluate the ability of the generative pre-trained transformer (GPT)-4o model to convert real-world coronary computed tomography angiography (CCTA) free-text reports into structured data and automatically identify CAD-RADS categories and P categories.
eHealth and Hypertensive Disorders of Pregnancy: Systematic Review.
J Med Internet Res
September 2025
Faculty of Medicine, The University of Sydney, Sydney, Australia.
Background: Hypertensive disorders of pregnancy (HDP) affect up to 10% of pregnancies and can have adverse short and long-term implications for women and their babies. eHealth interventions include any health service or treatment delivered using the internet and related technology that aims to facilitate, capture, or exchange knowledge. eHealth interventions are increasingly used across many health care settings with improved outcomes.
View Article and Find Full Text PDFEdwards syndrome: Neurocognitive and linguistic profile, diagnosis, overlaps and treatment.
Pol Merkur Lekarski
September 2025
NEAPOLIS UNIVERSITY, NEAPOLIS, CYPRUS.
Objective: Aim: To provide a comprehensive understanding of the profound developmental and medical challenges associated with this condition..
Patients And Methods: Materials and Methods: Τhis study employed a narrative review methodology, drawing upon a wide range of peer-reviewed scientific literature, clinical guidelines, and case studies.
Morphological features of the great saphenous vein in patients with chronic venous disease of the lower extremities undergoing the most common endovenous treatment techniques.
Pol Merkur Lekarski
September 2025
Kharkiv Clinical Hospital on Railway Transport No. 1 ≪Health Care Center≫ of Joint-Stock Company «Ukrainian Railways», Kharkiv, Ukraine.
Objective: Aim: The purpose was to identify the morphological features of the great saphenous vein in patients with chronic venous disease of the lower extremities undergoing treatment with endovenous high-frequency electric welding in automatic mode, endovenous laser ablation, and ultrasound-guided microfoam sclerotherapy.
Patients And Methods: Materials and Methods: The material for the comprehensive morphological study consisted of fragments of the great saphenous vein obtained from 32 patients with chronic venous disease of the lower extremities. The material was divided into three groups according to the endovenous treatment techniques applied.
Rational nutrition as a factor of healthy lifestyle and prevention of chronic non-communicable diseases.
Pol Merkur Lekarski
September 2025
VOLODYMYR DAHL EAST UKRAINIAN NATIONAL UNIVERSITY, KYIV, UKRAINE.
Objective: Aim: The aim is to conduct medical and sociological research on public awareness of the impact of rational nutrition on promoting human health and preventing chronic non-communicable diseases.
Patients And Methods: Materials and Methods: The research was conducted in 2022-2024 and involved 214 respondents of different ages and genders who were patients of outpatient clinics in Zhytomyr (Ukraine). Research methods included theoretical analysis of literary sources, medical and sociological (questionnaire), mathematical and statistical, system analysis, and logical generalization.