Use of nebulized naloxone to reverse methadone overdose - A case report and review of literature.

J Community Hosp Intern Med Perspect

Department of Emergency Medicine, University of Maryland Medical System, Midtown Campus, Baltimore, MD, USA.

Published: November 2019


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Article Abstract

Opioid use is a frequent cause of morbidity and mortality in the USA. We report a case of methadone overdose reversed with naloxone nebulization. Peripheral IV access can be difficult to obtain in patients with a history of IV drug abuse making needless routes of naloxone administration useful. When naloxone is administered as a bolus, chronically opioid dependent patients are more prone to violent withdrawal symptoms. When successful, nebulized naloxone reverses intoxication and allows the patient to self-titrate the discontinuation of naloxone when they are alert enough to remove the mask. Nebulized naloxone can provide needleless and noninvasive administration for the reversal of opioid overdose.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830244PMC
http://dx.doi.org/10.1080/20009666.2019.1659664DOI Listing

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Use of nebulized naloxone to reverse methadone overdose - A case report and review of literature.

J Community Hosp Intern Med Perspect

November 2019

Department of Emergency Medicine, University of Maryland Medical System, Midtown Campus, Baltimore, MD, USA.

Opioid use is a frequent cause of morbidity and mortality in the USA. We report a case of methadone overdose reversed with naloxone nebulization. Peripheral IV access can be difficult to obtain in patients with a history of IV drug abuse making needless routes of naloxone administration useful.

View Article and Find Full Text PDF