Three paternally imprinted regions are sequentially required in prenatal and postnatal mouse development.

Sci China Life Sci

School of Life Sciences and Technology, ShanghaiTech University, Shanghai, 201210, China.

Published: January 2020


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11427-019-1561-1DOI Listing

Publication Analysis

Top Keywords

three paternally
4
paternally imprinted
4
imprinted regions
4
regions sequentially
4
sequentially required
4
required prenatal
4
prenatal postnatal
4
postnatal mouse
4
mouse development
4
three
1

Similar Publications

The effect of unintended pregnancy on the development of parental-fetal attachment: a prospective cohort study.

BMC Pregnancy Childbirth

September 2025

Department of General Practice, Institute of Clinical Medicine, University of Turku and Turku University Hospital, Turun Yliopisto, Yleislääketiede, 20014 Turun Yliopisto, Turku, Finland.

Background: A strong parental (maternal/ paternal)-fetal attachment predicts a stronger parental-infant attachment after the child is born. An unintended pregnancy has been associated with weakened development of a maternal-fetal attachment. However, the knowledge of association between an unintended pregnancy and the development of a paternal-fetal attachment is scarce.

View Article and Find Full Text PDF

Rad51 and meiosis-specific Dmc1 catalyze homologous recombination (HR) between maternal and paternal chromosomes during meiosis in many sexual eukaryotes, generating three interhomolog (IH) recombination products: non-crossovers (NCOs), class I interference-sensitive crossovers (COs), and class II non-interfering COs. CO interference suppresses relatively close CO formation. Some COs form chiasmata, which physically connect homologous chromosomes and ensure proper chromosome segregation during meiosis I.

View Article and Find Full Text PDF

Gestational Trophoblastic Disease in Bahrain: Prevalence, Risk Factors, and Outcomes.

Cureus

August 2025

Obstetrics and Gynecology, Salmaniya Medical Complex, Manama, BHR.

Background Gestational trophoblastic disease (GTD) refers to a group of conditions linked to abnormal growth of trophoblastic tissue following conception. Although uncommon, early detection of GTD is vital due to the potential for progression and serious complications. The prevalence and presentation of GTD vary by region.

View Article and Find Full Text PDF

Angelman syndrome patient-derived neuron screen leads to clinical ASO rugonersen targeting UBE3A-ATS with long-lasting effect in monkeys.

Nucleic Acids Res

August 2025

Roche Pharma Research and Early Development, Neuroscience and Rare Disease discovery and translational area, Roche Innovation Center Basel, Basel 4070, Switzerland.

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal ubiquitin E3 ligase UBE3A, with no available treatment. Restoring UBE3A by downregulating the paternally cis-acting long noncoding antisense transcript (UBE3A-ATS) is a potentially disease modifying strategy. However, developing molecules targeting human UBE3A-ATS is challenging due to its selective expression in mature neurons and lack of sequence conservation across species.

View Article and Find Full Text PDF

Analysis of Insect Resistance and Ploidy in Hybrid Progeny of Transgenic Triploid Poplar 741.

Plants (Basel)

August 2025

Forest Tree Genetics and Breeding Laboratory, College of Forestry, Hebei Agricultural University, Baoding 071001, China.

With the increasing severity of forest pest problems, breeding insect-resistant varieties has become a crucial task for the sustainable development of forestry. The highly insect-resistant triploid Populus line Pb29, genetically modified with , served as the maternal parent in controlled hybridization with three paternal Populus cultivars. Hybrid progenies were obtained through embryo rescue and tissue culture.

View Article and Find Full Text PDF