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Background/aim: To describe imaging features of head and neck soft-tissue sarcomas.
Patients And Methods: Patients with a diagnosis of head and neck sarcoma between 2011 and 2015 were reviewed.
Results: There were a total of 62 patients (24 female; median age=60 years). Most common sarcomas were angiosarcoma, undifferentiated pleomorphic sarcoma and sarcoma not otherwise specified. They were most commonly located in cranial and neck superficial soft tissues. Average tumour size at presentation was 45 mm. One patient had metastasis at presentation (rhabdomyosarcoma); two had nodal disease (rhabdomyosarcoma and angiosarcoma) and two tumours contained calcification (chondrosarcoma and synovial sarcoma). Four arose after prior radiotherapy.
Conclusion: Unlike the more common diagnosis of squamous cell carcinoma, the majority of head and neck sarcomas present as large, solitary, superficial masses without lymph node enlargement. Identification of these features on imaging should raise suspicion of a sarcoma diagnosis, particularly in the setting of previous irradiation or genetic susceptibility.
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http://dx.doi.org/10.21873/anticanres.13831 | DOI Listing |
J Craniofac Surg
September 2025
Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an, China.
Salivary duct carcinoma (SDC) is a rare high-grade parotid malignancy prone to perineural spread. However, perineural spread of SDC has rarely been reported. The case of a 46-year-old male with SDC spread along the facial nerve (FN) is presented here.
View Article and Find Full Text PDFJ Craniofac Surg
September 2025
Viterbi Family Department of Ophthalmology, Division of Oculofacial Plastic and Reconstructive Surgery, Shiley Eye Institute, University of California, San Diego.
This study evaluates the clinical presentation, surgical management, and outcomes of silent sinus syndrome (SSS), with emphasis on the efficacy of simultaneous sinus and orbital surgery. A retrospective review was performed of 35 patients diagnosed with SSS at a tertiary care center between January 2004 and April 2024. All patients had radiographic evidence of maxillary sinus atelectasis and orbital floor resorption.
View Article and Find Full Text PDFLupus
September 2025
Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India.
A 16-year boy had a history of rash, oral ulcers, alopecia, photosensitivity, cheilitis, and weight loss, for which he was started on steroids, methotrexate, and hydroxychloroquine from outside. Three years later, he developed pericardial effusion and peripheral neuropathy, that were managed at an outside hospital. Later, he presented to us with weight loss, diffuse rash, left facial palsy, and left lateral rectus palsy.
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.
Fanconi Anemia (FA) is a heritable syndrome characterized by DNA damage repair deficits, frequent malformations and a significantly elevated risk of bone marrow failure, leukemia, and mucosal head and neck squamous cell carcinomas (HNSCC). Hematopoietic stem cell gene therapy can prevent marrow failure and lower leukemia risk, but mucosal gene therapy to lower HNSCC risk remains untested. Major knowledge gaps include an incomplete understanding of how rapidly gene-corrected cellular lineages could spread through the oral epithelium, and which delivery parameters are critical for ensuring efficient gene correction.
View Article and Find Full Text PDFJ Gerontol A Biol Sci Med Sci
September 2025
Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI.
Background: Poor olfaction may be associated with incident heart failure (HF) in older adults, but empirical evidence is scant.
Methods: We included 5,217 participants free of clinical HF and with a smell assessment in 2011-2013 from the Atherosclerosis Risk in Communities Study. Olfaction was measured by the 12-item Sniffin' Sticks odor identification test and defined as good (score 11-12), moderate (9-10), or poor (≤8).