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Background: Patient-reported outcomes (PROs) are frequently used for medical decision making, at the levels of both individual patient care and healthcare policy. Evidence increasingly shows that PROs may be influenced by patients' response shifts (changes in interpretation) and dispositions (stable characteristics).
Main Text: We identify how response shifts and dispositions may influence medical decisions on both the levels of individual patient care and health policy. We provide examples of these influences and analyse the consequences from the perspectives of ethical principles and theories of just distribution.
Conclusion: If influences of response shift and disposition on PROs and consequently medical decision making are not considered, patients may not receive optimal treatment and health insurance packages may include treatments that are not the most effective or cost-effective. We call on healthcare practitioners, researchers, policy makers, health insurers, and other stakeholders to critically reflect on why and how such patient reports are used.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737596 | PMC |
http://dx.doi.org/10.1186/s12910-019-0397-3 | DOI Listing |
Sci Adv
September 2025
Laoshan Laboratory, Qingdao, China.
Anthropogenic aerosols are an important driver of historical climate change but the climate response is not fully understood and the climate model simulations suffer large uncertainties. On the basis of a multimodel ensemble of historical aerosol forcing simulation for a period of global aerosol increase during 1965 to 1989, here, we show that the precipitation response shares a common southward displacement of tropical rain bands but the magnitude differs markedly among models, accounting for 76% of the intermodel uncertainty in zonal-mean precipitation change. Our analysis of atmospheric energetics further reveals key mechanisms for magnitude uncertainty: aerosol radiative forcing drives, cloud radiative feedback amplifies, and ocean circulation damps the intermodel uncertainty in cross-equatorial atmospheric energy transport change and the meridional shift of tropical rain bands.
View Article and Find Full Text PDFPhys Rev Lett
August 2025
Central China Normal University, Key Laboratory of Quark and Lepton Physics (MOE) and Institute of Particle Physics, Wuhan 430079, China.
Diffusion wake accompanying a Mach cone is a unique feature of the medium response to projectiles traveling at a speed faster than the velocity of sound. This is also the case for jet-medium interaction inside the quark-gluon plasma in high-energy heavy-ion collisions. It leads to a depletion of soft hadrons in the opposite direction of the propagating jet and, recently, has been observed in Z-jet events of Pb+Pb collisions at LHC.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Anatomy and Physiology, The University of Melbourne, Parkville, Victoria, Australia.
Food intake is a key regulator of the digestive system function; however, little is known about organ- and sex-specific differences in food-driven regulation. We placed male and female C57Bl/6 mice on time-restricted feeding (TRF), limiting access to food to an 8-hour window. Food was added either at dark (ZT12) or light (ZT0) onset for 14 days.
View Article and Find Full Text PDFPLoS One
September 2025
Guangxi Transportation Investment Group Co., Ltd., Nanning, Guangxi, China.
To investigate the axial compressive behavior of CFRP-PVC square tube-embedded aluminum concrete columns, five specimens and one control specimen without I-shaped aluminum were tested under uniaxial compression, with the number of CFRP layers and spacing as variable parameters. The failure modes, load-displacement responses, and mechanical properties such as peak load, ductility, stiffness, and energy dissipation were systematically analyzed. Results showed that the incorporation of I-shaped aluminum improved the peak load and ductility by an average of 48.
View Article and Find Full Text PDFTissue Eng Part A
September 2025
Department of Chemical and Materials Engineering, Faculty of Engineering, The University of Auckland, Auckland, New Zealand.
Spatially and temporally controlled drug delivery is an important field to address the limitations of conventional pharmaceutical administration. While many effective controlled drug delivery systems exist, the repertoire of systems that additionally present a beneficial mechanical environment to cells remains scarce. To address this, a comprehensive release study of fluorescein as a model drug, and the corticosteroid dexamethasone, from poly(-isopropylacrylamide)/polypyrrole (pNIPAM/PPy) conducting polymer hydrogels is presented within this study.
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