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Primary cardiac sarcomas are rare tumors with poor prognosis. Intimal sarcoma, a mesenchymal malignant tumor described mainly in the great vessels, may rarely involve the heart. Herein we describe the case of a 70-years-old female who was found to have a left atrial mass during an investigation of a new onset dyspnea. The patient underwent surgery and the resected mass was found to be an intimal sarcoma. The objectives of this report were to describe a case of this rare disease entity and to discuss its pathological and molecular findings based on relevant literature.
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http://dx.doi.org/10.1016/j.annpat.2019.08.001 | DOI Listing |
Case Rep Oncol
February 2025
Department of Cardiac, Thoracic and Vascular Surgery, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Introduction: Primary malignant aortic tumors are rare and diagnosis can be difficult due to the variety of clinical manifestations. This malignant disease, which originates in the intima or medial layers of the aorta, presents a complex diagnostic and therapeutic dilemma. Due to their insidious growth and nonspecific symptoms, they are often diagnosed postmortem.
View Article and Find Full Text PDFCardiovasc Pathol
July 2025
Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Republic of Korea. Electronic address:
Cardiac undifferentiated pleomorphic sarcomas (UPS) are extremely rare tumors that typically arise in the left atrium. They behave highly aggressively, requiring multimodality treatment when complete surgical resection is not feasible. Nevertheless, there is ongoing debate regarding the efficacy of adjuvant radiation therapy and the associated risk of radiation-induced cardiotoxicity.
View Article and Find Full Text PDFBr J Cancer
July 2025
Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Background: The incidence and predictors of brain metastases (BrM) from sarcoma remain poorly characterized. We aimed to determine the cumulative incidence (CuI) and risk factors for BrM.
Methods: We retrospectively analyzed data from all sarcoma patients who presented to our center (2006-2023).
JACC Case Rep
July 2025
Department of Cardiology, Yokohama Municipal Citizen's Hospital, Yokohama, Japan.
Malignant tumors of the aortic valve are extremely rare and challenging to diagnose. Here, we present a case of a 59-year-old woman with an intimal sarcoma of the aortic valve that led to acute aortic regurgitation (AR) and recurrent acute coronary syndrome (ACS). The patient initially presented with an out-of-hospital cardiac arrest due to ACS and underwent emergent percutaneous coronary intervention.
View Article and Find Full Text PDFEur J Cardiothorac Surg
August 2025
Division of Thoracic Surgery, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan.
Objectives: Intimal sarcoma is a rare vascular malignancy with a poor prognosis and no established treatment. This study aimed to identify clinicopathological and transcriptomic factors associated with disease progression to uncover potential therapeutic targets.
Methods: Ten patients with surgically resected intimal sarcoma were included.