Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Di-butyl phthalate (DBP) is commonly added to make plastics softer and more pliable and is found in a variety of consumer and industrial products. Alarmingly high levels of DBP have been detected in water and sediment as DBP leaches from products. These levels are concerning and have led the Environmental Protection Agency to label DBP as a priority environmental pollutant and the European Commission to label DBP as a priority substance. Given the ubiquitous presence of DBP globally and continuous exposure to DBP, studies on the developmental toxicity of DBP are needed. The endocrine disrupting effects of DBP are well documented, but developmental toxicity of DBP during critical developmental time windows is understudied. Here, we investigate the developmental effects of DBP exposure during early development. We find defects in craniofacial development including a decrease in overall cranial size in DBP treated embryos, but the intraocular distance was increased compared to controls. Further investigation of jawbone development demonstrated loss of and disorganization of cartilage development. Defects in vascular innervation and neuronal patterning were also noted. Here we conclude that exposure to DBP during crucial time windows of embryonic development is toxic to craniofacial development.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10646-019-02100-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy and Safety of Aldosterone Synthase Inhibitors for Resistant Hypertension: A Systematic Review and Meta-Analysis.
Rev Cardiovasc Med
August 2025
Department of Emergency Medicine, General Practice Medical Center, National Clinical Research Center for Geriatrics, West China Hospital, 610041 Chengdu, Sichuan, China.
Background: Compared to patients with controllable hypertension, those with resistant hypertension (RH) have a higher incidence of cardiovascular complications, including stroke, left ventricular hypertrophy, and congestive heart failure. Therefore, an urgent need exists for improved management and control, along with more effective medications. Aldosterone synthase inhibitors (ASIs) are newly emerging drugs that have gradually attracted an increasing amount of attention.
View Article and Find Full Text PDFAssociation Between Admission Blood Pressure and In-hospital Mortality and Long-term Mortality of Patients With ST-elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A China Acute Myocardial Infarction Registry Study.
Rev Cardiovasc Med
August 2025
Center for Coronary Heart Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases of China, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037 Beijing, China.
Background: Globally, acute myocardial infarction (AMI) is among the primary causes of mortality. The ideal approach for blood pressure (BP) management for patients experiencing ST-segment elevation myocardial infarction (STEMI) who receive percutaneous coronary intervention (PCI) remains a topic of ongoing debate. Current guidelines on BP management lack specific recommendations for STEMI patients undergoing PCI, resulting in substantial individual variability and uncertainties in clinical treatment strategies.
View Article and Find Full Text PDFSynthesis and performance study of potassium-based flame-retardant groups grafted onto nitrocellulose.
Phys Chem Chem Phys
September 2025
School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
To analyse the issues of high muzzle flame intensity and the easy migration of insensitive agents in conventional insensitive propellants, this study synthesizes modified nitrocellulose grafted with carboxymethyl potassium groups by a two-step process, starting from the molecular structure of nitrocellulose (NC), the principal component of propellants. First, the denitration reaction was performed to reduce part of the nitrate ester groups on the surface of NC to hydroxyl groups, followed by an etherification reaction to achieve directional grafting of carboxymethyl potassium groups. Compared with conventional flame retardant/insensitive systems based on nitrogen, phosphorus, or DBP (dibutyl phthalate), potassium-based functional groups exhibit superior thermal stability and environmental friendliness.
View Article and Find Full Text PDFThe feasibility of noninvasive blood pressure monitoring in infants with a birth weight under 500 grams.
J Perinatol
September 2025
Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
Objective: To quantify agreement between oscillometric non-invasive blood pressure (NIBP) and invasive arterial blood pressure (IBP) in infants <500 g during the first postnatal week.
Study Design: Retrospective cohort of infants with a birth weight <500 g admitted to a tertiary NICU (2011-2023). Paired IBP-NIBP readings obtained within 1 min were analyzed.
Integration of network toxicology, machine learning and single-cell sequencing reveals the effects of soil pollutants on prostate cancer.
Ecotoxicol Environ Saf
September 2025
Department of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address:
Background: Prostate cancer (PRAD) is a common malignancy in men, and exposure to soil pollutants may contribute to its development. And exposure to soil pollutant has been linked to its development, as well as to other diseases including cardiovascular disorders, neurological conditions, and additional cancers.
Methods: This study integrates network toxicology, machine learning, and advanced technologies to investigate the mechanisms through which soil pollutants affect prostate cancer.