Mechanisms of Leukemia Evolution: Lessons from a Congenital Syndrome.

Cancer Cell

Division of Pediatric Hematology and Oncology, Schneider Children's Medical Center of Israel, Petach Tikva 49100, Israel; Sackler Medical School, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel. Electronic address:

Published: August 2019


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Article Abstract

Studies of the mechanisms of acute leukemia transformation from a preleukemic state in humans are hampered by the absence of clinical preleukemia syndromes. In this issue of Cancer Cell, Labuhn et al. provide a functional genomics view on the leukemic evolution from congenital preleukemia in children with Down syndrome.

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http://dx.doi.org/10.1016/j.ccell.2019.07.004DOI Listing

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