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http://dx.doi.org/10.1177/1753193419867007 | DOI Listing |
Microsc Microanal
September 2025
Division of Anatomy, Center for Anatomy and Cell Biology, RPMI, Medical University Vienna, Währinger Strasse 13, 1090 Vienna, Austria.
The dermal arteries of the finger are organized in discrete units. We hypothesized that the anatomy of the dermal arterial units and the number and complexity of dermal Sucquet-Hoyer canals (SHCs) differ between the tip and center of the pad of the thumb. To test this, digital HREM volume datasets (voxel dimensions of 1-3 μm³) were created from biopsies harvested from the thumb tip and pad of six body donors.
View Article and Find Full Text PDFCureus
July 2025
Orthopedic Surgery, University of Arizona College of Medicine, Phoenix, USA.
Background: Joint denervation procedures continue to demonstrate promise in the management of chronic pain and functional improvement in joint pathology of the hand and wrist. As our understanding of these techniques evolves, a detailed comprehension of neuroanatomy, including the precise relationships and contributions of sensory innervation to targeted joints, is critical for optimizing outcomes.
Methods: Freshly thawed frozen upper extremity cadaveric specimens were analyzed under the direction of two fellowship-trained hand surgeons.
J Clin Orthop Trauma
November 2025
Department of Orthopaedics, Dhanalakshmi Srinivasan Medical College Hospital, Siruvachur, Tamilnadu, India.
Thumb-in-palm deformity significantly limits hand function in arthrogryposis multiplex congenita (AMC), resulting from intricate interactions between contracted thumb-index web skin, restrictive intrinsic musculature, joint instability, and compromised extrinsic tendons, collectively causing thumb adduction, flexion, and poor opposition. Due to the complexity of this deformity, surgical outcomes have historically varied. We introduced a severity-based classification system-mild, moderate, or severe-to guide treatment decisions.
View Article and Find Full Text PDFThe transition to bipedal locomotion is a key event in human evolution, involving substantial changes to the skeleton, including the bones of the hands and feet (autopods). Hominins evolved a more muscular and opposable thumb while the other fingers are relatively shorter, enhancing manipulative capacity. The feet evolved robust first toes and short lateral toes to meet the challenges of bipedal walking and running.
View Article and Find Full Text PDFJ Med Chem
September 2025
Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.
Dengue viruses (DENVs) infect approximately 400 million people each year, and currently, there are no effective therapeutics available. To explore potential starting points for antiviral drug development, we conducted a large-scale crystallographic fragment screen targeting the RNA-dependent RNA polymerase (RdRp) domain of the nonstructural protein 5 (NS5) from DENV serotype 2. Our screening, which involved 1108 fragments, identified 60 hit compounds across various known binding sites, including the active site, N pocket, and RNA tunnel.
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