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http://dx.doi.org/10.1002/adhm.201900754 | DOI Listing |
J Control Release
August 2025
Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China. Electronic address:
The clinical translation of DDS is still one of the most challenging issues for the further development of therapeutic breakthroughs, especially for cancer and complex diseases. This review provides a critical overview of the factors that influence the translation of DDS, highlighting biological and non-biological barriers that challenge their success. Additionally, their impacts are conceptually clarified in biological aspects, including immunity, biocompatibility and the tumor microenvironment, on the performance and site-selectivity of DDS.
View Article and Find Full Text PDFLung Cancer
September 2025
Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Republic of Korea. Electronic address:
Lung cancer remains the leading cause of cancer-related mortality, and immune checkpoint inhibitors (ICIs) have revolutionized its treatment. However, immunotherapy responses vary significantly among patients, and adverse effects, such as immune-related pneumonitis, pose clinical challenges. Both the tumor macroenvironment (TMaE) and tumor microenvironment (TME) play pivotal roles in modulating immunotherapy outcomes; however, the complex crosstalk between them remains insufficiently characterized.
View Article and Find Full Text PDFDiscov Appl Sci
August 2025
Department of Metallurgical, Materials, and Biomedical Engineering (MMBME), The University of Texas at El Paso (UTEP), 500 W University Ave, 79968 El Paso, TX, USA.
In vitro 3D tissue models within microfluidic-based microphysiological systems (MPS) provide controlled and reproducible platforms for quantification of isolated cellular processes in response to biochemical or biophysical stimulus. This study demonstrates the development of a 3D MPS with a dual-chamber, closed-capillary circuit microfluidic culture platform to study chemotherapy drug efficacy in vitro for aggressive malignancies such as breast cancer and glioblastoma. This novel microfluidic system was used to model HER2 + breast cancer (BCTM-SKBR3) co-cultured with cardiac (CTM-AC16) tissue for proof-of-concept chemotherapy-induced cardiotoxicity studies.
View Article and Find Full Text PDFCell Mol Biol Lett
August 2025
Departments of Neuroscience & Physiology, Cell & Developmental Biology and Radiation Oncology, SUNY Upstate Medical University, 4706 Institute for Human Performance, Syracuse, NY, 13210, USA.
Primary bone tumors and bone metastases represent significant challenges in oncology. Radiotherapy is an important adjuvant treatment for several primary bone and musculoskeletal tumors, as well as for palliative care for metastatic bone lesions. While effective in these applications, patients receiving skeletal radiation face a lifelong risk of fragility fracture at the irradiated sites, among other complications.
View Article and Find Full Text PDFBiofabrication
August 2025
Terasaki Institute for Biomedical Innovation, 21100 Erwin St, Woodland Hills, California, 91367, UNITED STATES.
Embolization of blood vessels is a widely used treatment for liver cancer. Novel shear-thinning hydrogels (STH) have been developed to address the need for safe and effective local delivery of embolic agents and therapeutics. However, embolization therapies are optimized in animal models, which often differ from humans at the cellular, tissue, and organ levels.
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