98%
921
2 minutes
20
This is the case of a 27-year-old male patient with a newly diagnosed extensive lymphomatoid papulosis type A involving cosmetically sensitive areas (e.g. face), who refused to be treated with a low dose of methotrexate, as recommended by the published literature. The natural course of the disease was proved to be strikingly satisfying though, with a complete regression of all skin lesions at the 4-week follow-up, including an ulcerated nodule 3 x 3 cm in dimension, which was expected to heal at least in months. We report this case to reconsider weighting the risks and the short-term benefits of methotrexate treatment, even in the case of an extensive disease.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662440 | PMC |
http://dx.doi.org/10.1155/2019/1765210 | DOI Listing |
Cureus
July 2025
Dermatology, The Derm Institute of West Michigan, Caledonia, USA.
Lymphomatoid papulosis (LyP) is a rare cutaneous lymphoproliferative disorder involving the dysregulation of CD30-positive T-cells that accumulate in the skin. The accumulation of CD30-positive T-cells leads to the development of papulonodular lesions, which typically follow a protracted course and often resolve spontaneously in a matter of days to weeks. This case report describes a 44-year-old male patient who initially presented to the dermatology office with recurrent nodules under the right eye.
View Article and Find Full Text PDFJ Clin Med
July 2025
Porphyria and Rare Diseases Unit, San Gallicano Dermatological Institute-IRCCS, 00144 Rome, Italy.
: Lymphomatoid papulosis (LyP) is a primary cutaneous CD30-positive T-cell lymphoproliferative disorder presenting with self-healing erythematous papulonodular lesions that may ulcerate and scar. Treatment varies by lesion extent, location, and severity. : We describe a 57-year-old man with acral LyP successfully treated with chlormethine gel (CG).
View Article and Find Full Text PDFFront Immunol
July 2025
Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Background: Lymphomatoid papulosis (LyP) is a rare, chronic, recurrent, self-healing, indolent cutaneous lymphoproliferative disorder. Histologically, it resembles malignant lymphoma; however, its clinical manifestations are predominantly characterized by benign behaviors, including recurrent papules, nodules, and necrotic lesions.
Case Presentation: We report a case of a middle-aged female who initially presented with a giant ulcer on the right foot and was surgically treated at another hospital as a keratoacanthoma (KA).
JAAD Case Rep
August 2025
Department of Dermatology, University of California, Irvine, California.
An Bras Dermatol
June 2025
Department of Dermatology, Venereology and Oncodermatology, University of Pécs, Pécs, Hungary.