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Time perception in living organisms, especially mammals, and understanding the timing of their internal organs, have always been the topic of interest in neuroscience. In this study, our theory considers the photonic behavior on time control by some particular or some block of neurons. Photon emission by mitochondria has regular timing in intercellular process. In other words, due to the main mitochondrial function of cellular respiration as well as the source of photon emission, it is possible to deduce photon at a specific rate in TANs (Tonically Active Neurons). If photoreceptors exist in the neurons of the nervous system, photons can be received at a regulated time. Thereby, neurons can produce a constant-frequency signal for subsequent stimuli. Our studies conducted in the CNS (Central Nervous System) and TANs, and it seems that photoreceptors are present in TANs. Photons are interpreted by a series of neurons and produce an oscillating rhythm. These rhythms can be the basis of the body's chronological activity in different areas of the CNS. If this hypothesis is true, it can be deduced that an independent factor, excluding circadian activities, exists for living activities. Different neuronal structures will also be responsible for understanding the time. Although this hypothesis is far from a complete evaluation, it can compensate for some of the other problems. For instance, a series of inconsistencies that occur in some neurological diseases, such as Parkinson diseases can be well justified by this hypothesis.
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http://dx.doi.org/10.1016/j.mehy.2019.109248 | DOI Listing |
J Comp Physiol A Neuroethol Sens Neural Behav Physiol
September 2025
Centre of Marine Sciences (CCMAR), University of Algarve, Campus de Gambelas, Faro, 8005- 139, Portugal.
Chemical sensing of the surrounding environment is crucial for many aspects of bivalve biology, such as food detection and predator avoidance. Aquatic organisms strongly depend on chemosensory systems; however, little is known about chemosensory systems in bivalves. To understand how the carpet shell clam (Ruditapes decussatus) senses its surrounding chemical environment, we used an electrophysiological technique - the electro-osphradiogram - to assess the sensitivity of the osphradium to different putative odorants (amino acids, bile acids) and odours (predator-released cues and signals from con- and heterospecific bivalves).
View Article and Find Full Text PDFJ Immunol
September 2025
Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Texas A&M School of Medicine, Bryan, TX, United States.
Mounting evidence supports a critical role for central nervous system (CNS) glial cells in neuroinflammation and neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's Disease (PD), Multiple Sclerosis (MS), as well as neurovascular ischemic stroke. Previously, we found that loss of the PD-associated gene leucine-rich repeat kinase 2 (Lrrk2) in macrophages, peripheral innate immune cells, induced mitochondrial stress and elevated basal expression of type I interferon (IFN) stimulated genes (ISGs) due to chronic mitochondrial DNA engagement with the cGAS/STING DNA sensing pathway. Here we report that loss of LRRK2 results in a paradoxical response in microglial cells, a CNS-specific macrophage population.
View Article and Find Full Text PDFPLoS One
September 2025
University of Southampton, Electronics and Computer Science, Southampton, Hampshire, United Kingdom.
Social Anxiety Disorder (SAD) is a prevalent and debilitating condition characterized by heightened anxiety and avoidance behaviors in social situations. Despite the availability of treatment options, remission rates for SAD remain low, highlighting the need for more effective interventions. To support the development of more effective therapies, a better understanding of the psychophysiological mechanisms underlying SAD is needed.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
July 2025
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Beijing 100191, China.
Cistanches Herba(CH) is a famous tonic traditional Chinese medicine, with the effects of tonifying kidney Yang, nourishing kidney Yin, replenishing essence and blood, and moistening the intestines to relieve constipation. Modern pharmacological studies have shown that CH has anti-aging, anti-fatigue, immunomodulatory, neuroprotective, and anti-aging activities, serving as an ideal raw material for the development of pharmaceuticals and health products. In 2023, CH was added in the catalog of medicinal and food substances, which provided policy support for its application in conventional food products and expanding pathways for industrial diversification.
View Article and Find Full Text PDFBehav Brain Res
August 2025
Department of Engineering Design, Indian Institute of Technology Madras, India. Electronic address:
Test Anxiety (TA) is known to impair the heart-brain interaction affecting both the central and autonomic nervous systems. The impairment is often assumed to be uniform, overlooking individual variability in stress response. This study explores how heart-brain dysregulation in TA may manifest conditionally, shaped by individual differences.
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