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Antrodia cinnamomea or Antrodia camphorata is a distinctive mushroom of Taiwan, which is being used as a traditional medicine to treat various health-related conditions. More than 78 compounds have been identified in A. cinnamomea. Large numbers of phytochemical studies have been carried out in A. cinnamomea due to the high amount of terpenoids. Besides that, the extracts and active components of A. cinnamomea were reported to have various biological activities including hepatoprotective, antihypertensive, antihyperlipidemic, anti-inflammatory, antioxidant, antitumor, and immunomodulatory activities. In this review article, we have summarized the recent findings of A. cinnamomea and its molecular mechanisms of action in various disease models. PRACTICAL APPLICATIONS: A. cinnamomea, medicinal fungus used in traditional medicine in Taiwan also possess high market value. Aim of the present review is to highlight the compounds present in A. cinnamomea and their different pharmacological activities in preventing/cure various diseases/disorders. A. cinnamomea can be potentially developed into health foods or drugs.
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http://dx.doi.org/10.1111/jfbc.12936 | DOI Listing |
Eur J Pharmacol
September 2025
Department of Emergency Medicine, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Emergency Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:
Background: This study seeks to provide preclinical evidence demonstrating the potential of Antrocinol, a derivative of antrocin derived from the active compound of Antrodia cinnamomea, as a promising small-molecule drug candidate for overcoming drug-resistant hepatocellular carcinoma (HCC).
Methods: We developed Lenvatinib-resistant Huh-7 and HepG cell lines (Huh-7/LR, HepG2/LR) to evaluate their viability and apoptotic response to Antrocinol. Autophagy-dependent cell death was assessed in Huh-7/LR cells using Z-VAD-FMK and shATG5 transfection.
Foods
August 2025
Yantai Edible and Medicinal Mushroom Technology Innovation Center, Key Laboratory of Molecular Module-Based Breeding of High Yield and Abiotic Resistant Plants in Universities of Shandong, College of Horticulture, Ludong University, Yantai 264025, China.
, a renowned rare medicinal fungus in China, is rich in active components, exhibiting pharmacological effects, such as liver protection, hypoglycemic activity, and anti-tumor properties. Aiming to address the lack of horizontal comparative studies on volatile components of under different culture methods and the limitations of traditional detection methods, this study investigated the mycelia of cultured by solid-state culture (SAC), liquid culture (LAC), and dish culture (DAC). The flavor profiles were comprehensively evaluated using a combination of electronic tongue (E-tongue), electronic nose (E-nose), gas chromatography-ion mobility spectrometry (GC-IMS), and multivariate statistical methods.
View Article and Find Full Text PDFPersoonia
June 2025
Université catholique de Louvain (MUCL, BCCM), Earth and Life Institute - Microbiology (ELIM), Université catholique de Louvain, Croix du Sud 2 bte L7.05.06, 1348 Louvain-la-Neuve, Belgium.
() is becoming a very large and complex genus and the species definition is becoming a challenge, as for many other groups of . comprises 79 species up to date. However, this number is probably still largely underestimated.
View Article and Find Full Text PDFJ Ethnopharmacol
July 2025
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing, 100191, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, State Key Laboratory of Natural and Biomimetic Drugs, NHC Key
J Ethnopharmacol
July 2025
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing, 100191, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, State Key Laboratory of Natural and Biomimetic Drugs, NHC Key