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Article Abstract
Herein we describe an unprecedented Ru-catalyzed site-selective and regiospecific annulation of benzoic acids with propargylic carbonates. The weakly coordinating carboxylic acid moiety outperformed other typically used directing groups in C-H activation, including ketone, nitrile, sulfonamide, amide and strongly coordinating nitrogen heterocycles. This is an important step towards the application of C-H activation reactions in complex (functional) real-world molecules.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611066 | PMC |
| http://dx.doi.org/10.1039/c9sc01703h | DOI Listing |
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