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Objective: to construct collectively with nursing professionals bundle for best practices of cold chain maintenance of immunobiological agents conservation at the local level.
Method: a qualitative research of convergent care type. Bundle construction was guided by the Evidence-Based Practice criterion. Data collection was carried out from October to December 2016, through five workshops, with the participation of 21 professionals from 7 vaccination rooms of a municipality of Minas Gerais State. The framework developed by Morse and Field was adopted for data analysis.
Results: through bundle, care is taken regarding refrigeration equipment temperature monitoring, contingency plan performance, recyclable ice coil setting and chamber use as refrigeration equipment.
Final Considerations: the chosen interventions began to guide the practice and promote a care based on safety and quality.
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http://dx.doi.org/10.1590/0034-7167-2018-0406 | DOI Listing |
Cureus
August 2025
Internal Medicine, Unidade Local de Saúde do Alto Ave, Guimarães, PRT.
Toxic epidermal necrolysis (TEN) is a rare, life-threatening mucocutaneous condition, most commonly triggered by drugs, with particularly high mortality in elderly populations. The medications most frequently associated with TEN include antibiotics such as sulfamethoxazole-trimethoprim (sulfonamides), penicillins, cephalosporins, and quinolones (e.g.
View Article and Find Full Text PDFFront Immunol
August 2025
Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Introduction: The Neotropical tick is the primary vector of , the causative agent of Brazilian spotted fever, a disease associated with high fatality rates. Tick saliva, a complex mixture of bioactive molecules essential for successful blood feeding, facilitates pathogen transmission and modulates host immune responses. A comprehensive evaluation of the salivary gland transcriptome database reveals that protease inhibitors are abundantly expressed molecules in tick saliva during feeding.
View Article and Find Full Text PDFPharm Nanotechnol
July 2025
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, Irbid 21163, Jordan.
In this comprehensive exploration of advanced nanocarriers for atopic dermatitis (AD) therapy, we explored a spectrum of innovative delivery systems, each with unique attributes poised to revolutionize topical drug administration. Lipid nanoparticles, including solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), have emerged as stalwarts offering controlled drug release and enhanced skin penetration. Vesicular systems such as liposomes, ethosomes, transfersomes, and niosomes are versatile in their ability to encapsulate hydrophilic and lipophilic agents and overcome barriers to drug permeation.
View Article and Find Full Text PDFBraz J Microbiol
September 2025
Institute of Technology in Immunobiologicals, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
This study aimed to evaluate the biofilm formation and disinfectant tolerance of Stenotrophomonas maltophilia strains originated from hospitalized patients during the COVID-19 pandemic. Nine strains were isolated from different clinical departments at a hospital in Brazil, were identified by VITEK®2, Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry, 16S rRNA sequencing, and 23S rRNA PCR. Enterobacterial Repetitive Intergenic Consensus-Polymerase Chain Reaction (ERIC-PCR), Fourier-transform infrared (FTIR) spectroscopy, antimicrobial susceptibility testing, and biofilm formation and disinfectant tolerance tests were applied.
View Article and Find Full Text PDFAn Bras Dermatol
May 2025
Departament of Dermatology, Clinical Hospital, Faculty of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.
Background: Pyoderma gangrenosum (PG) is a rare dermatosis often associated with systemic diseases. There are autoinflammatory mechanisms with neutrophilic infiltrate and necrosis. Due to the high morbidity, variable response to therapy and lack of treatment standardization, PG constitutes a highly burdensome condition.
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