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Article Abstract
Fluorescence spectra, H NMR, thermoanalysis and molecular modeling were used to investigate the host-guest inclusion system of hydroxypropyl-β-cyclodextrin (HPβCD) with capsaicin. Job's plot was employed to confirm a 1:2 host-guest stoichiometry. Phase solubility study indicated that the apparent stability constant was 3.76 × 10 M. With the enhancing fluorescence of capsaicin complexation with HPβCD, a spectrofluorimetric method approach to determine the capsaicin in bulk aqueous solution was developed. Linearity was achieved wide ranges (0.05-60 μg/mL), with low detection limit of 0.04 μg/mL, and the relative standard deviation was 1.30%. Application to the analysis of chili powder samples obtained a satisfactory recovery of 99.5-105.6%.
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| http://dx.doi.org/10.1016/j.saa.2019.117278 | DOI Listing |
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