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Purpose Of Review: The first computer-assisted personalized sedation (CAPS) device was developed to address the growing demand for routine endoscopy procedures in the United States in the early 2000s. This review will describe the environment that gave rise to CAPS and summarize the design of that first device. It will then discuss the market forces that led to the fall of CAPS, with sales of the device ending 2 years after commercialization.
Recent Findings: CAPS was initially conceived as a means to enable proceduralists to administer conscious sedation with propofol safely. In the nearly 20 years since its conception, the expectations of patients and proceduralists for endoscopy sedation, have evolved from conscious sedation to deep. Due to the increased risk inherent in deep sedation, future CAPS devices should be tools for anesthesiologists, not proceduralists.
Summary: Over $2 billion are spent annually for anesthesia services in routine endoscopic procedures for low-risk patients; a spending rate that is not sustainable. CAPS, in an 'anesthesia oversight' model similar to medical supervision, has a future as a cost-efficient means for anesthesia services to provide sedation in endoscopy and other nonoperating room venues. Anesthesiologists should work with medical device companies and payers to develop a CAPS 'anesthesia oversight' model.
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http://dx.doi.org/10.1097/ACO.0000000000000761 | DOI Listing |
J Cancer Res Clin Oncol
September 2025
Cancer Treatment and Nuclear Cardiology Department, Al Azhar University, Cairo, Egypt.
Background: High-dose-rate (HDR) brachytherapy is essential in the treatment of locally advanced cervical cancer. While Iridium-192 (Ir-192) is commonly used, its short half-life imposes logistical and financial constraints, particularly in low- and middle-income countries (LMICs). Cobalt-60 (Co-60), with a longer half-life and lower operational costs, is a viable alternative.
View Article and Find Full Text PDFHum Brain Mapp
September 2025
Department of Neuropediatrics, General Pediatrics, Diabetology, Endocrinology, Social Pediatrics, University Children's Hospital, Tübingen, Germany.
Subject motion is a significant problem for the analysis of functional MRI data and is usually described by "total displacement" or "scan-to-scan displacement". Neither parameter, however, takes into account voxel size, which clearly is relevant for the actual effects of motion on the data. Consequently, it is hitherto impossible to compare motion between subjects/studies acquired using different voxel dimensions, precluding the development of generally applicable recommendations for fMRI quality control procedures.
View Article and Find Full Text PDFNucleic Acids Res
September 2025
School of Software, Shandong University, Jinan 250101, Shandong, China.
Spatial transcriptomics (ST) reveals gene expression distributions within tissues. Yet, predicting spatial gene expression from histological images still faces the challenges of limited ST data that lack prior knowledge, and insufficient capturing of inter-slice heterogeneity and intra-slice complexity. To tackle these challenges, we introduce FmH2ST, a foundation model-based method for spatial gene expression prediction.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Orthopaedic Surgery, Kobe Red Cross Hospital, Hyogo, Japan.
This study aims to clarify the dynamic changes in the cervical lordotic angle (CLA) during normal swallowing using an automated motion analysis method. Physiological cervical lordosis is crucial for spinal alignment and musculoskeletal function. While previous studies have noted the relevance of cervical curvature in clinical contexts, its dynamic modulation during swallowing has not been well studied.
View Article and Find Full Text PDFRadiat Oncol
September 2025
Department of Breast Sarcoma and Endocrine Tumors, Karolinska University Hospital, Stockholm, Sweden.
Background: Stereotactic Body Radiotherapy (SBRT) has been proven to be a safe and effective alternative to surgery in patients with metastatic primary sarcoma. However, data describing tumor response in relation to the given radiotherapy dose is lacking. Therefore, this study aims at analyzing efficacy and dose-response relationship in a retrospective cohort.
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