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Introduction: This randomized clinical trial assessed the effect of preoperative intraoral cryotherapy application on the success rate of inferior alveolar nerve blocks (IANBs) in patients with symptomatic irreversible pulpitis (SIP).
Methods: One hundred four patients with SIP were randomly distributed into 2 groups: control and cryotherapy groups. In the control group, patients received an IANB injection with 2% lidocaine. In the cryotherapy group, intraoral cryotherapy application was performed for 5 minutes after the IANB. Endodontic therapy was then conducted 15 minutes after the IANB injection. If the patients reported moderate or severe pain during the procedure, the IANB was defined as "unsuccessful," and a supplementary injection was administered.
Results: All patients reported profound lip numbness. The overall success rate for the IANBs was 43.3%. In the cryotherapy group, the success rate of the IANBs was 55.8%, whereas in the control group it was 30.8% (P < .05).
Conclusions: Intraoral cryotherapy application increased the success rate of IANBs in mandibular molar teeth with SIP. However, supplemental anesthesia techniques may still be required to provide profound pulpal anesthesia in many cases.
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http://dx.doi.org/10.1016/j.joen.2019.05.001 | DOI Listing |
Neotrop Entomol
September 2025
Kunming Branch of Yunnan Provincial Tobacco Company, Kunming, China.
Successful biological control requires accurate knowledge of the host preference of the released parasitoid. Telenomus remus Nixon (1973) is an effective parasitoid of Spodoptera frugiperda (J.E.
View Article and Find Full Text PDFJ Oral Sci
September 2025
Department of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, Semmelweis University.
Purpose: This study evaluated how the formation of various types of precipitates affects the accuracy of electronic apex locators in determining the working length.
Methods: Two hundred and forty extracted human maxillary incisors were selected. A total of eight groups were used: four groups (n = 30) for the application of different irrigants; saline, sodium hypochlorite (5.
Sci Justice
September 2025
Departamento de Medicina Legal, Bioética, Medicina do Trabalho e Medicina Física e Reabilitação, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address:
Short Tandem Repeats (STRs) are the standard technique used in forensic genetics for individual identification due to their high polymorphism and robustness. Although Capillary Electrophoresis (CE) enables the analysis of many STRs, Next-Generation Sequencing (NGS) offers enhanced resolution and the ability to detect STRs' isoalleles and their flanking regions, enhancing the discrimination power of this analysis. Despite the fact that STR kits for NGS are well standardized for evaluating forensic samples, there is no data on their effectiveness in differentiating monozygotic (MZ) twins, which are indistinguishable by CE.
View Article and Find Full Text PDFBMJ Open
September 2025
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
Introduction: Intracranial atherosclerosis is the main cause of stroke globally, with acute large vessel occlusive (LVO) stroke being a predominant contributor to stroke-related mortality. In recent years, aspiration thrombectomy (AT) has emerged as a novel therapeutic method for treating acute LVO stroke. The purpose of this study aims to investigate the safety and efficacy of AT alone or combined with stent retriever thrombectomy (SRT) in the treatment of acute LVO stroke METHODS AND ANALYSIS: This is a multicentre and observational real-world study involving patients diagnosed with acute LVO stroke.
View Article and Find Full Text PDFEur J Vasc Endovasc Surg
September 2025
Department of Vascular Surgery, University Hospital, LMU Munich, Munich, Germany.
Objective: This study aimed to evaluate treatment indications, compare therapeutic approaches, and assess outcomes in patients with infrarenal penetrating aortic ulcers (iPAUs).
Methods: This was a retrospective, multicentre, observational study of patients with iPAUs treated between January 2018 and December 2022 across 12 European centres. Treatment strategies included open surgical repair (OSR) and endovascular techniques, including balloon expandable stent grafts (BESGs), covered endovascular reconstruction of the aortic bifurcation (CERAB), and endovascular aortic repair (EVAR) using bifurcated or tube grafts.