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Bisphenol A and its analogues belong to the class of endocrine disrupting chemicals, massively employed by industries to produce polycarbonate and epoxy resins, designed to be in direct contact with foodstuffs. Their leaching from the canned packaging into its content results in food contamination. This review aims at offering a country-specific overview of the occurrence of bisphenols in six main categories of foodstuff marketed in the EU, based on monitoring studies performed in the 27 EU countries for which data are available and prevalently published in the last five years. The general overview of the literature data shows that concentration values of BPs detected into foodstuff is lower in Northern Europe than Southern Europe. A probable daily intake was hypothesized for some countries to provide an EU population exposure assessment. The consumption of canned meat and vegetables is responsible of PDI values higher than those of other food categories. These data emphasize that food and beverage monitoring should deserve greater attention especially by European countries for which no studies are available and especially with regards to bisphenols other than BPA whose limits are not set by the European regulations and whose toxicity has not been fully established.
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http://dx.doi.org/10.1016/j.fct.2019.110575 | DOI Listing |
Bisphenol A (BPA) and its analogs are collectively termed bisphenol compounds (BPs), which are predominantly utilized in the manufacturing of polycarbonate plastics and epoxy resins. BPs are ubiquitous in diverse environmental matrices, human tissues, and metabolic products. Extensive research has demonstrated that BPs exert adverse effects on the nervous, reproductive, immune, and metabolic systems.
View Article and Find Full Text PDFMar Environ Res
August 2025
Istanbul University, Institute of Marine Science and Management, Vefa, 34134, Istanbul, Turkey.
Bisphenol analogues and phthalate acid esters are well-known endocrine disruptors. Information on detailed distribution and partitioning of Bisphenol A (BPA) and Phthalate acid esters (PAEs) in port sediments is essential for a better understanding of their residence time in sediment, influence of anthropogenic activities in port, and port sustainability, especially in terms of environmental impact. Herein, this study determined the concentrations of BPA and PAEs in sediments that are collected from 38 stations from Istanbul ship-ports and scrutinized distribution, possible source identification and potential environmental risk assessment.
View Article and Find Full Text PDFIn Vivo
August 2025
Division of Oral Diagnosis and General Dentistry, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, Japan.
Background/aim: Eugenol dimer (-eugenol), a representative ortho-bisphenol, has been reported to have potent antioxidant/anti-inflammatory activity. To clarify the antioxidant/anti-inflammatory mechanisms of -eugenol, we investigated its involvement in heme oxygenase-1 (HO-1) expression and anti-inflammatory activity.
Materials And Methods: HO-1 expression in RAW264.
Life (Basel)
July 2025
Laboratory of Toxicology and Risk Assessment, Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.
Bisphenol A (BPA) is an endocrine-disrupting chemical with estrogen-like activity, known to impair immune function. BPA may act as a pro-inflammatory agent, reducing immune response efficacy, increasing bacterial load in E. coli infections, and altering immune responses in parasitic infections (Leishmania major, Nippostrongylus brasiliensis, Toxocara canis) through cytokine and regulatory T-cell modulation.
View Article and Find Full Text PDFBiomedicines
August 2025
First Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.
: Bisphenols (BPs) and especially bisphenol S (BPS), an analog of bisphenol A (BPA), are widely used and induce oxidative stress, resulting in the inhibition of cell proliferation and induction of apoptosis which all are crucial for reproduction, the progression of pregnancy, and fertility. The present study integrates trophoblastic cells as an in vitro model to provide evidence and investigate the molecular interactions regarding placenta-related pregnancy complications after cytotoxic exposure to BPS. : Human endometrial epithelial adenocarcinoma Ishikawa cell lines and trophoblastic cells were cultured.
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