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Beds are key, scarce medical resources in hospitals. The bed occupancy rate (BOR) amongst different departments within large tertiary hospitals is very imbalanced, a situation which has led to problems between the supply of and the demand for bed resources. This study aims to balance the utilization of existing beds in a large tertiary hospital in China. We developed a data-driven hybrid three-stage framework incorporating data analysis, simulation, and mixed integer programming to minimize the gaps in BOR among different departments. The first stage is to calculate the length of stay (LOS) and BOR of each department and identify the departments that need to be allocated beds. In the second stage, we used a fitted arrival distribution and median LOS as the input to a generic simulation model. In the third stage, we built a mixed integer programming model using the results obtained in the first two stages to generate the optimal bed allocation strategy for different departments. The value of the objective function, , represents the severity of the imbalance in BOR. Our case study demonstrated the effectiveness of the proposed data-driven hybrid three-stage framework. The results show that decreases from 0.7344 to 0.0409 after re-allocation, which means that the internal imbalance has eased. Our framework provides hospital bed policy makers with a feasible solution for bed allocation.
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http://dx.doi.org/10.1155/2019/7370231 | DOI Listing |
J Chem Inf Model
September 2025
Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, U.K.
We present the protolysis-targeting chimera (PROTAC) Conformer Generator, a fast and knowledge-based tool for generating robust conformational ensembles of PROTACs and other chimeric degraders. The modeling protocol integrates conformer generation, rigid-body ternary complex (TC) assembly, and conformational sampling strategies that address the inherent flexibility and complexity of these molecules. Each modeled TC is evaluated using a clash-score and a surface-score, designed to prioritize sterically and geometrically plausible models with favorable protein surface interactions.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.
The analysis of box-score performance indicators has traditionally been used to classify player roles in women's basketball based on the five conventional positions: point guard, shooting guard, small forward, power forward, and center. However, this framework may not reflect the current tactical and functional demands of the game. The aim of this study was to identify and redefine functional player roles in professional women's basketball using performance data derived from actual competition.
View Article and Find Full Text PDFJ Healthc Leadersh
August 2025
Department of Medical Equipment Technology, College of Applied Medical Science, Majmaah University, Majmaah, 11952, Saudi Arabia.
Introduction: Clinical Engineering Departments (CEDs) face growing challenges in managing rapidly evolving medical technologies and increasing equipment inventories under constrained budgets and limited human resources. These pressures often result in strained staffing capacity and imbalanced workload distribution. This study aimed to develop and validate a metrics-driven hybrid staffing model to optimize workforce allocation and improve workload efficiency across National Guard Health Affairs (NGHA) hospitals in Saudi Arabia.
View Article and Find Full Text PDFMath Biosci Eng
July 2025
Department of Applied Mathematics, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.
Understanding the metabolic adaptations of cancer cells is crucial for uncovering potential therapeutic targets and improving treatment strategies. In this study, we present a hybrid modeling framework that combines Physics-Informed Neural Networks (PINNs) and Universal PINNs (UPINNs) to investigate glucose-lactate metabolism in glioblastoma cell lines. We first employed PINNs to infer critical model parameters governing glucose uptake and phenotypic switching in tumor cells, demonstrating high accuracy using synthetic data.
View Article and Find Full Text PDFSci Rep
September 2025
Department of Mechanical Engineering, College of Engineering, University of Ha'il, Ha'il City, 81451, Saudi Arabia.
Accurate assessment of intracranial aneurysm rupture risk, particularly in Middle Cerebral Artery (MCA) aneurysms, relies on a detailed understanding of patient-specific hemodynamic behavior. In this study, we present an integrated framework that combines Computational Fluid Dynamics (CFD) with Proper Orthogonal Decomposition (POD) and machine learning (ML) to efficiently model pulsatile blood flow using a Casson non-Newtonian fluid model, without incorporating fluid-structure interaction (FSI). Patient-specific vascular geometries were reconstructed from DICOM imaging data and simulated using ANSYS Fluent to capture key hemodynamic factors, including velocity components, pressure, wall shear stress (WSS), and oscillatory shear index (OSI).
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