Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: The long-term prognosis of asthma with airflow obstruction is poorly understood in Japan. The aim of this retrospective 26-year study was to investigate the long-term mortality risk of airflow obstruction in asthmatics.
Methods: Using data from the Omuta City Air Pollution-related Health Damage Cohort Program, mortality risk ratios of airflow obstruction in Japanese Individuals were analyzed by Cox proportional hazards models. Airflow obstruction was considered to be present when the forced expiratory volume in 1 sec (FEV)/forced vital capacity ratio was <0.7 and FEV predicted was <80% based on spirometry.
Results: Among the 3146 victims with chronic respiratory diseases, 697 with adult asthma were selected. Median follow-up period was 26.3 (range 0.9-40.9) years. The airflow obstruction group (n = 193) showed significantly higher rates of mortality related to respiratory problems (risk ratio [95% confidence interval] 1.51 [1.86-1.93], P = 0.0017) and asthma attacks (1.86 [1.30-2.66], P = 0.0011) than the without airflow obstruction group (n = 504). Airflow obstruction was an independent risk factor for both respiratory-related (1.84 [1.36-2.49], P = 0.0001) and all-cause (1.44 [1.17-1.76], P = 0.0008) mortality after adjustment for age, sex, body mass index, and smoking status. More severe airflow obstruction was significantly associated with poorer prognosis.
Conclusions: This long-term cohort program revealed the impacts of asthma with airflow obstruction as an independent mortality risk. Findings suggest that intervention and prevention of airflow obstruction can reduce long-term mortality in patients with asthma.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.alit.2019.04.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An Alternative and Efficient Topicalization Technique for the Difficult Airway: A Case Series.
Cureus
August 2025
Anaesthesia and Surgical Intensive Care, Changi General Hospital, Singapore Health Services, Simei, SGP.
Effective airway topicalization is essential for awake tracheal fiberoptic intubation (ATI) in patients with a difficult airway. Traditional methods often result in inadequate anesthesia at the laryngeal inlet, leading to patient discomfort, procedural difficulty, and excessive local anesthetic (LA) use. This case series introduces a novel, resource-efficient topicalization technique using standard operating theatre equipment.
View Article and Find Full Text PDFPrediction of the course of chronic obstructive pulmonary disease by blood biomarkers.
Biomed Khim
September 2025
Republican Scientific and Practical Center of Pulmonology and Phthisiatry, Minsk, Belarus.
Chronic obstructive pulmonary disease (COPD) is one of the most common pathologies of the respiratory system; it is characterized by increasing airflow limitation. The course of COPD is unstable and is often accompanied by periods of exacerbation, when respiratory symptoms of the disease significantly increase. The frequency of COPD exacerbations is an important predictor of its course, allowing to predict the decline in lung tissue function and the outcome of the disease.
View Article and Find Full Text PDFPulsating airflow jets delivered via nasal cannula offer a promising, comfortable, non-invasive alternative to continuous positive airway pressure (CPAP) for treating obstructive sleep apnea (OSA). However, the fluid dynamic mechanisms by which pulsatile flow influences upper airway pressure remain poorly understood in anatomically realistic geometries. This study used large eddy simulations (LES) to examine pressure and flow characteristics of pulsating nasal jets within a patient-specific upper airway model.
View Article and Find Full Text PDFQuantifying Neuromuscular and Pressure Force Dynamics in Obstructive Sleep Apnea: A Novel Computational Fluid Dynamics Approach Using Airway Wall Acceleration.
J Biomech Eng
September 2025
Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States, Department of Radiology and Medical Imaging, Cincinnati Children's Hospital Medical Center, Cincinnati, OH,
Obstructive sleep apnea (OSA) is characterized by recurrent upper airway collapse during sleep, resulting from interactions between aerodynamic forces, neuromuscular activation, and tissue properties. This study introduces a novel methodology for analyzing airway wall dynamics by incorporating acceleration-based metrics into computational fluid dynamics (CFD) simulations to better understand the pathophysiology of airway collapse in OSA. A patient with OSA underwent magnetic resonance imaging (MRI) to capture airway anatomy and motion under sleep-like sedation.
View Article and Find Full Text PDFImpact of COVID-19 and lockdown on outcomes of COPD patients in Turkey: lessons for the future.
BMC Pulm Med
August 2025
Faculty of Medicine, Department of Pulmonary Diseases, Cukurova University, Adana, Turkey.
Background: The COVID-19 pandemic and related public health restrictions have substantially altered healthcare access and delivery, particularly for patients with chronic conditions such as chronic obstructive pulmonary disease (COPD). This study aimed to evaluate the impact of the COVID-19 pandemic and lockdown measures on COPD-related symptoms and hospital admissions, and to compare these outcomes with the pre-pandemic period.
Methods: This multicenter cross-sectional study was conducted between July 2021 and February 2022 across ten tertiary pulmonary outpatient clinics in Turkey.