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http://dx.doi.org/10.1111/ggi.13638 | DOI Listing |
Curr Diabetes Rev
August 2025
College of Pharmacy, Zunyi Medical University, Zunyi, 563006, China.
Background: Epigenetic regulation constitutes critical molecular mechanisms underlying the pathogenesis of diabetes and disease progression. While substantial mechanistic investigations exist, the field lacks systematic mapping of research trends, collaborative networks, and emerging frontiers.
Objectives: To conduct the first comprehensive bibliometric evaluation of epigenetic studies in diabetes mellitus and its complications (2014-2024), identifying key research domains, international collaboration patterns, and innovative investigative directions to inform strategic research planning and highlight opportunities for innovative therapeutic approaches.
Transbound Emerg Dis
September 2025
Department of Animal Biosciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
In September 2023, Sweden experienced its first ever outbreak of African swine fever (ASF). One year later, in September 2024, Sweden was declared free from ASF. One of the first actions taken toward control and eradication was an intensive search for wild boar carcasses.
View Article and Find Full Text PDFJ Exp Med
November 2025
Department of Microbiology and Immunology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Tissue-resident memory T cells (TRM) remain in nonlymphatic barrier tissues for extended periods and are deeply involved in immune memory at the site of inflammation. Here, we employed multilayered single-cell analytic approaches including chromatin, gene, and protein profiling to characterize a unique CD4+ TRM subset present in the inflamed gut mucosa of Crohn's disease patients. We identified two key transcription factors, RUNX2 and BHLHE40, as regulators of pathologically relevant CD4+ TRM.
View Article and Find Full Text PDFPlant Biotechnol J
September 2025
International Center for Biotechnology, University of Osaka, Osaka, Japan.
N-Glycosylation critically influences the efficacy, safety and pharmacokinetic properties of biopharmaceuticals. Plant expression platforms offer multiple advantages for the production of N-glycosylated proteins, but their use is impeded by the presence of plant-specific N-glycan epitopes, which raise concerns of possible immunogenicity to humans. In this study, N-glycoengineered Nicotiana benthamiana plants that produce more homogeneous N-glycans without plant-specific epitopes were generated using multiplex CRISPR/Cas9 genome editing.
View Article and Find Full Text PDFPrev Nutr Food Sci
August 2025
Department of Biotechnology, Graduate School of Engineering, The University of Osaka, Osaka 565-0871, Japan.
B vitamins are integral in maintaining human health. Owing to its high B vitamin contents, tempeh serves as an excellent plant-based option to achieve an adequate intake of these nutrients through diet. In order to investigate the metabolomic profile of tempeh and modulate the contents of vitamins B and B in it, we employed microbial interventions using two species of lactic acid bacteria (LAB) and various inoculum sizes in the soaking step during tempeh production.
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