98%
921
2 minutes
20
Purpose: To evaluate the potential of full-iterative reconstruction (IR) for improving image quality of the cystic artery on CT angiography and to assess observer performance.
Methods: Thirty patients who underwent both liver dynamic CT and conventional angiography were included in this retrospective study. All CT data were reconstructed through filtered back projection (FBP), adaptive iterative dose reduction 3D (AIDR3D), and forward-projected, model-based, iterative reconstruction solution (FIRST), respectively. In objective study, we analyzed mean ΔCT numbers (the difference between the HU peak of the vessel and the background) and full-width at tenth-maximum (FWTM) of three parts of the cystic artery by profile curve method comparing the three reconstructions. Subjectively, visualization was evaluated using a four-point scale performed by two blinded observers. ANOVA was used for statistical analysis.
Results: In all parts of the cystic artery, the mean ΔCT number of FIRST was shown to be significantly better than that of FBP and AIDR3D (p < 0.05). FWTM in FIRST was the smallest in all of the vessels. The mean visualization score was significantly better with FIRST than with other CT reconstructions (p < 0.05).
Conclusions: The FIRST algorithm led to improved CTA visualization of the cystic artery.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1007/s11604-019-00839-x | DOI Listing |
Am J Physiol Cell Physiol
September 2025
Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA.
We previously demonstrated the CFTR correctors VX-445 (elexacaftor) and S-VX-121 (vanzacaftor) potentiate heterologously-expressed BK channels, as well as in primary human bronchial epithelial cells (HBEs). This potentiation of BK resulted in altered vasoreactivity and neuronal excitability. We postulated novel compounds could be identified that would potentiate BK while not affecting CFTR.
View Article and Find Full Text PDFJ Gastrointest Surg
September 2025
Department of Surgical Oncology, Cancer Institute (WIA), 38, Sardar Patel Road, Chennai 600036, India. Electronic address:
Cureus
August 2025
Department of Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, JPN.
Hemorrhagic cholecystitis (HC) is a rare but life-threatening condition. While anticoagulant therapy is a known risk factor, the coronavirus disease 2019 (COVID-19) has recently emerged as another trigger. We experienced a severe case of perforated HC complicated by hemoperitoneum in a patient presenting both risk factors.
View Article and Find Full Text PDFOrphanet J Rare Dis
September 2025
Department of Health Sciences, University of Milan, Via Antonio di Rudinì 8, Milano, Italy.
Background: Cellular senescence is a biological process in which the cell cycle is arrested in response to DNA damage caused by different endogenous and exogenous stimuli. In senescent cells, activation of intracellular cascade induces epigenetic, morphological and metabolic changes. Among them, senescent status is characterized by an alteration of the epigenome and the establishment of a peculiar senescence-associated secretory phenotype (SASP), which contributes to the extracellular matrix remodeling and senescence spreading.
View Article and Find Full Text PDFJ Cyst Fibros
August 2025
Department of Respiratory Medicine, University Hospital Wales, Cardiff and Vale University Health Board, USA.
Background: Cystic fibrosis (CF) is a progressive inherited disorder that primarily affects the lungs. With recent breakthroughs in effective treatments for CF that increase life-expectancy, a higher prevalence of age-related comorbidities has been reported including cardiovascular disease, stroke and cognitive decline. Despite the known relationship between cardiovascular health and cerebrovascular function, very little is known about brain blood flow and oxygen metabolism in people with CF (PwCF).
View Article and Find Full Text PDF