Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Cyclomarins are highly potent antimycobacterial and antiplasmodial cyclopeptides isolated from a marine bacterium (Streptomyces sp.). Previous studies have identified the target proteins and elucidated a novel mode of action, however there are currently only a few studies examining the structure-activity relationship (SAR) for both pathogens. Herein, we report the synthesis and biological evaluation of 17 novel desoxycyclomarin-inspired analogues. Optimization via side chain modifications of the non-canonical amino acids led to potent lead structures for each pathogen.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/chem.201901640 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Wearable bioelectronics for skin cancer management.
Biomaterials
August 2025
Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address:
Wearable bioelectronics have transformed modern biomedical applications by enabling seamless integration with biological tissues, providing continuous, comprehensive, and personalized healthcare. Skin cancer, particularly melanoma, poses a significant clinical challenge due to its high metastatic potential and associated mortality. Traditional diagnostic approaches face limitations in accuracy, accessibility, and reproducibility, while existing treatments are often constrained by systemic toxicity and therapeutic resistance.
View Article and Find Full Text PDFOlfactory preferences of the allium leafminer, an emerging pest in North America: comparison of three experimental bioassays.
J Econ Entomol
September 2025
European Biological Control Laboratory (EBCL USDA ARS), Montferrier-sur-lez, France.
Evaluating the olfactory preferences of emerging insect pests is critical to develop monitoring tools and improve early detection and management strategies. Here the chemical ecology and olfactory preferences of the allium leafminer Phytomyza gymnostoma Loew (Diptera: Agromyzidae), an invasive pest in North America affecting allium crops such as leeks and onions, were investigated. Three bioassay methods were assessed under laboratory conditions: wind tunnel, Y-tube olfactometer, and arena bioassay.
View Article and Find Full Text PDFCat, dog, and horse allergies: emerging new insights.
Turk J Pediatr
September 2025
Division of Allergy and Asthma, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Animal allergens, particularly those from cats, dogs, and horses, are significant risk factors for the development of allergic diseases in childhood. Managing animal allergies requires allergen avoidance and, when this is not feasible, specific immunotherapy. Patient history remains the cornerstone of diagnosis, providing the foundation for diagnostic algorithms.
View Article and Find Full Text PDFRandomized Controlled Trial of Impact of Mobile Health Technologies on Human Papillomavirus Vaccination Uptake in Mothers of Vaccine-Eligible Girls in Lagos, Nigeria (mHealth-HPVac).
JCO Glob Oncol
May 2025
Department of Obstetrics and Gynaecology, Stanford University School of Medicine, Stanford, CA.
Purpose: Expanding high-risk human papillomavirus (HPV) vaccine coverage in resource-constrained settings is critical to bridging the cervical cancer gap and achieving the global action plan for elimination. Mobile health (mHealth) technology via short message services (SMS) has the potential to improve HPV vaccination uptake. The mHealth-HPVac study evaluated the effectiveness of mHealth interventions in increasing HPV vaccine uptake among mothers of unvaccinated girls aged 9-14 years in Lagos, Nigeria.
View Article and Find Full Text PDFChemical Composition, Antioxidant, and Antibacterial Activities of Mezilaurus duckei (Lauraceae).
Chem Biodivers
September 2025
Instituto De Química, Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil.
Mezilaurus duckei, a Brazilian endemic tree species found exclusively in the Amazon Rainforest, is primarily exploited for timber in construction. Due to its endangered status, this study aimed to investigate the chemical profile and biological properties of the ethanolic extract and its phases derived from M. duckei leaves.
View Article and Find Full Text PDF