98%
921
2 minutes
20
The 2014 West African Ebola virus disease (EVD) outbreak is the largest and deadliest EVD epidemic to date, resulting in fivefold more cases than all other outbreaks combined. This outbreak was particularly devastating to healthcare workers in West Africa and resulted in several EVD patients being medically evacuated for treatment in the U.S. and Europe. Governmental agencies provide recommendations for triaging and testing patients with EVD, however best laboratory practices are still unknown and are very resource dependent.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1053/j.semdp.2019.04.007 | DOI Listing |
Vaccine
September 2025
Department of Tropical Medicine, Medical Microbiology & Pharmacology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96813, USA. Electronic address:
Filoviruses, including the well-known Ebola virus, are among the most lethal pathogens known. The current vaccine landscape is constrained by stringent cold chain requirements making vaccine deployment challenging, especially in regions with limited infrastructure. ERVEBO®, the sole FDA-approved filovirus vaccine, requires ultra-cold storage.
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom.
Deciding when to enforce or relax non-pharmaceutical interventions (NPIs) based on real-time outbreak surveillance data is a central challenge in infectious disease epidemiology. Reporting delays and infection under-ascertainment, which characterise practical surveillance data, can misinform decision-making, prompting mistimed NPIs that fail to control spread or permitting deleterious epidemic peaks that overload healthcare capacities. To mitigate these risks, recent studies propose more data-insensitive strategies that trigger NPIs at predetermined times or infection thresholds.
View Article and Find Full Text PDFElife
September 2025
Department of Biochemistry & Biophysics and Bioengineering, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Cryptic pockets are of growing interest as potential drug targets, particularly to control protein-nucleic acid interactions that often occur via flat surfaces. However, it remains unclear whether cryptic pockets contribute to protein function or if they are merely happenstantial features that can easily be evolved away to achieve drug resistance. Here, we explore whether a cryptic pocket in the Interferon Inhibitory Domain (IID) of viral protein 35 (VP35) of Zaire ebolavirus aids its ability to bind double-stranded RNA (dsRNA).
View Article and Find Full Text PDFChemistryOpen
September 2025
Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, 61519, Egypt.
Ebola virus (EBOV), one of the deadliest diseases, is responsible for infecting individuals with hemorrhagic fever syndrome, which remains an ongoing worldwide health concern. The extremely deadly nature and virulence of EBOV illness illuminate the imperative need to evolve effective curative agents. Viral protien (VP35) acts as an Achilles heel for EBOV reproduction and also interacts with numerous human proteins, which leads to impairing the immune system.
View Article and Find Full Text PDFMol Ther
August 2025
Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230022, China; Department of Laboratory Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230036, China; Key Labora
Filoviruses, including Ebola and Marburg viruses, present significant global health challenges due to their high mortality rates. Despite the availability of several Ebola virus vaccines, none provide cross-protection against multiple filovirus species. In this study, we developed recombinant live attenuated measles virus-based vaccine candidates designed to express Ebola or Marburg virus glycoproteins and generate virus-like particles for pan-filovirus immunization.
View Article and Find Full Text PDF