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The emergence of life in a prebiotic world is an enormous scientific question of paramount philosophical importance. Even when life (in any sense we can define it) can be observed and replicated in the laboratory, it is only an indication of one possible pathway for life emergence, and is by no means be a demonstration of how life really emerged. The best we can hope for is to indicate plausible chemical-physical conditions and mechanisms that might lead to self-organizing and autopoietic systems. Here we present a stochastic simulation, based on chemical reactions already observed in prebiotic environments, that might help in the design of new experiments. We will show how the definition of simple rules for the synthesis of random peptides may lead to the appearance of networks of autocatalytic cycles and the emergence of memory.
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http://dx.doi.org/10.3390/life9020033 | DOI Listing |
Molecules
August 2025
Frumkin Institute of Physical Chemistry and Electrochemistry Russian Academy of Sciences, Leninsky prospekt 31-4, Moscow 119071, Russia.
In the context of chlorate's application as a cathodic reagent of power sources, the mechanism of its electroreduction has been studied in electrochemical cells under diffusion-limited current conditions with operando spectrophotometric analysis. Prior to electrolysis, the electrolyte is represented as an aqueous mixed NaClO + HSO solution (both components being non-electroactive within the potential range under study), without addition of any external electroactive catalyst. In the course of potentiostatic electrolysis, both the cathodic current and the ClO concentration demonstrate a temporal evolution clearly pointing to an autocatalytic mechanism of the process (regions of quasi-exponential growth and of rapid diminution, separated by a narrow maximum).
View Article and Find Full Text PDFLife (Basel)
July 2025
Department of Chemistry & Biochemistry, University of San Diego, San Diego, CA 92110, USA.
Extant core metabolic cycles such as the TCA cycle and its related analog pathways utilize carboxylic acids as metabolites, with thioesters playing a key role. We examine if sugars from the potentially autocatalytic formose reaction can be converted to carboxylic acids in the absence of enzymes by calculating the thermodynamics and kinetics of such pathways. We zero in on a mechanism involving the addition of a thiol to an aldehyde, followed by intramolecular disproportionation to form a thioester that can be hydrolyzed into its carboxylic acid.
View Article and Find Full Text PDFReact Chem Eng
August 2025
School of Molecular Sciences, Arizona State University, Tempe, AZ 85287.
Biological products and specimens often require consistent ultracold storage to preserve their integrity. Existing time-temperature indicators (TTIs) are inadequate for monitoring ultracold conditions at the individual aliquot level. We adapted the autocatalytic permanganate-oxalate reaction to create visual TTIs functional below 0 °C.
View Article and Find Full Text PDFJ Chem Phys
August 2025
Faculty of Synthetic Biology, Shenzhen University of Advanced Technology, Shenzhen 518055, China.
As a leading candidate for prebiotic synthesis of carbohydrates, the formose reaction has been the subject of extensive investigation. However, formaldehyde's reactivity enables competing pathways that divert the formose condensation, generating dead-end products. Here, we employ our recently developed roto-translationally invariant potential-driven molecular dynamics to investigate the side pathways in the formose reaction network, identifying several new reaction mechanisms.
View Article and Find Full Text PDFJ Hazard Mater
August 2025
Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 602105, India; Department of Civil Engineering, University Centre for Research & Development, Chandigarh University, Gharuan, Mohali, Punjab, India; Institute for Nanotechno
Bioaerosols are a major transmission route for respiratory infections. Metal oxide materials sterilize air via contact oxidation and reactive oxygen species (ROS). Bacteria rely on autocatalytic network for survival, where a single node change can impact the entire network.
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